Elevated Blood Pressure (≥120/80 mmHg) Is Associated with Elevated Serum Plasminogen Activator Inhibitor-1, Low Birth Weight, and Family History of Diabetes in Young Normal Weight Japanese Women.
机构：[1]Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women's University, Nishinomiya, Japan.[2]Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women's University, Kobe, Japan.[3]Research Institute for Nutrition Sciences, Mukogawa Women's University, Nishinomiya, Japan.[4]Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan.[5]Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Japan.[6]Department of Food Sciences and Nutrition, School of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Japan.[7]Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, Kobe, Japan.[8]Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, China.内科科室内分泌科昆明医科大学附属第一医院[9]Department of Medicine, Kohnan Kakogawa Hospital, Kakogawa, Japan.
Objective: We examined whether elevated blood pressure (BP) (≥120/80 mmHg) was associated with several anthropometric, metabolic, and clinical variables, including the family history of type 2 diabetes (FHD) and low birth weight, in young normal weight Japanese women. Methods: BP, body composition, and fasting glucose, insulin, lipids, lipoproteins, apolipoproteins, and adipokines were measured in 332 young Japanese women. They received a questionnaire on birth weight and FHD. Results: The prevalence of low birth weight was 2.4% and that of positive FHD was 22.9%. Homeostasis model assessment-insulin resistance averaged <1.5 and did not differ cross-sectionally between 32 women with elevated BP and 300 women with normal BP although mean body mass index was higher in the former than in the latter (21.7 ± 2.9 kg/m2 vs. 20.8 ± 2.2 kg/m2, P = 0.02). Women with elevated BP had higher fat mass index (P = 0.02) and trunk fat percentage (P = 0.04). They had lower high-density lipoprotein (HDL) cholesterol and apolipoprotein A1 (both P = 0.01) while fasting triglycerides and apolipoprotein B did not differ. In addition, they had higher plasminogen activator inhibitor-1 (PAI-1) (P = 0.001). Furthermore, the prevalence of low birth weight (9.4% vs. 1.7%, P = 0.03) and positive FHD (40.6% vs. 20.0%, P = 0.01) was higher in women with elevated BP. Multivariable logistic regression analyses revealed that elevated BP was independently associated with PAI-1 [odds ratio (OR); 1.05, 95% confidence interval (CI): 1.02-1.08, P = 0.001], low birth weight (OR: 12.3, 95% CI: 2.3-67.3, P = 0.04), and FHD (OR: 3.0, 95% CI: 1.3-7.9, P = 0.01). Conclusion: Elevated BP was associated with positive FHD, low birth weight, and elevated serum PAI-1 in young normal weight Japanese women.
第一作者机构：[1]Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women's University, Nishinomiya, Japan.[2]Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women's University, Kobe, Japan.
通讯作者：
通讯机构：[1]Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women's University, Nishinomiya, Japan.[3]Research Institute for Nutrition Sciences, Mukogawa Women's University, Nishinomiya, Japan.[9]Department of Medicine, Kohnan Kakogawa Hospital, Kakogawa, Japan.[*1]Research Institute for Nutrition Sciences Mukogawa Women’s University 6-46, Ikebiraki-cho Nishinomiya Hyogo 663-8558 Japan
推荐引用方式(GB/T 7714)：
Honda Mari,Tsuboi Ayaka,Minato-Inokawa Satomi,et al.Elevated Blood Pressure (≥120/80 mmHg) Is Associated with Elevated Serum Plasminogen Activator Inhibitor-1, Low Birth Weight, and Family History of Diabetes in Young Normal Weight Japanese Women.[J].Metabolic Syndrome And Related Disorders.2022,20(2):88-93.doi:10.1089/met.2021.0071.
APA：
Honda Mari,Tsuboi Ayaka,Minato-Inokawa Satomi,Takeuchi Mika,Kurata Miki...&Fukuo Keisuke.(2022).Elevated Blood Pressure (≥120/80 mmHg) Is Associated with Elevated Serum Plasminogen Activator Inhibitor-1, Low Birth Weight, and Family History of Diabetes in Young Normal Weight Japanese Women..Metabolic Syndrome And Related Disorders,20,(2)
MLA：
Honda Mari,et al."Elevated Blood Pressure (≥120/80 mmHg) Is Associated with Elevated Serum Plasminogen Activator Inhibitor-1, Low Birth Weight, and Family History of Diabetes in Young Normal Weight Japanese Women.".Metabolic Syndrome And Related Disorders 20..2(2022):88-93
