机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院病理科医技科室[2]Department of Dental Research, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, China[3]Department of Pathology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China
Objective: Lung adenocarcinoma (LUAD) is a common malignant tumor with a poor prognosis. The present study aimed to screen the key genes involved in LUAD development and prognosis. Methods: The transcriptome data for 515 LUAD and 347 normal samples were downloaded from The Cancer Genome Atlas and Genotype Tissue Expression databases. The weighted gene co-expression network and differentially expressed genes were used to identify the central regulatory genes for the development of LUAD. Univariate Cox, LASSO, and multivariate Cox regression analyses were utilized to identify prognosis-related genes. Results: The top 10 central regulatory genes of LUAD included IL6, PECAM1, CDH5, VWF, THBS1, CAV1, TEK, HGF, SPP1, and ENG. Genes that have an impact on survival included PECAM1, HGF, SPP1, and ENG. The favorable prognosis genes included KDF1, ZNF691, DNASE2B, and ELAPOR1, while unfavorable prognosis genes included RPL22, ENO1, PCSK9, SNX7, and LCE5A. The areas under the receiver operating characteristic curves of the risk score model in the training and testing datasets were .78 and .758, respectively. Conclusion: Bioinformatics methods were used to identify genes involved in the development and prognosis of LUAD, which will provide a basis for further research on the treatment and prognosis of LUAD.
基金：
Regional Fund Project of the National Natural Science Foundation of China; Yunnan Provincial Department of science and Technology-Kunming Medical University applied basic research joint special major project [82060423, 202001AY0700 1-007]
基金编号：82060423 202001AY0700 1-007
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类|4 区医学
小类|4 区卫生保健与服务4 区卫生政策与服务
最新[2023]版：
大类|4 区医学
小类|4 区卫生保健与服务4 区卫生政策与服务
JCR分区：
出版当年[2022]版：
Q4HEALTH CARE SCIENCES & SERVICESQ4HEALTH POLICY & SERVICES
最新[2023]版：
Q3HEALTH CARE SCIENCES & SERVICESQ3HEALTH POLICY & SERVICES
第一作者机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming, China
共同第一作者：
通讯作者：
通讯机构：[1]The First Affiliated Hospital of Kunming Medical University, Kunming, China[*1]Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.
推荐引用方式(GB/T 7714)：
Luo Xuan,Xu Jian Guo,Wang ZhiYuan,et al.Bioinformatics Identification of Key Genes for the Development and Prognosis of Lung Adenocarcinoma[J].INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING.2022,59:doi:10.1177/00469580221096259.
APA：
Luo, Xuan,Xu, Jian Guo,Wang, ZhiYuan,Wang, XiaoFang,Zhu, QianYing...&Bian, Li.(2022).Bioinformatics Identification of Key Genes for the Development and Prognosis of Lung Adenocarcinoma.INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING,59,
MLA：
Luo, Xuan,et al."Bioinformatics Identification of Key Genes for the Development and Prognosis of Lung Adenocarcinoma".INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING 59.(2022)
