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Elevated peripheral Neuregulin-1 protein levels in non-medicated focal epilepsy patients.

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收录情况： ◇ SCIE

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机构： [1]Department of Science and Education, First Affiliated Hospital of Kunming Medical University, Kunming, China [2]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China

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关键词： Neuregulin 1 Focal epilepsy Pathogenesis

摘要：

The Neuregulin-1 (NRG-1) gene has been identified as a susceptibility gene for schizophrenia. Schizophrenia and epilepsy shared some common clinical manifestations and common pathogenesis. Therefore, it is necessary to explore whether there is a relationship between NRG-1 and epilepsy. This study aimed to investigate the expression level of NRG-1 in peripheral blood of non-medicated patients with first-onset focal epilepsy.A total of 83 non-medicated first-onset focal epilepsy patients and 80 healthy controls were involved in this study. Serum NRG-1 protein levels were determined by ELISA.Compared to healthy controls (mean ± SD, 3.97 ± 2.37), NRG-1 protein levels were statistically significantly higher in patients (mean ± SD, 5.37 ± 3.48) (P = 0.006).Our findings suggest that NRG-1 protein may play a role in the pathogenesis of focal epilepsy, which provides insights into the search for epilepsy potential therapeutic markers and new drug treatment targets.Copyright © 2022. Published by Elsevier Ltd.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

JCR分区：

出版当年[2022]版：

Q4 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 1.9 最新[2023版] 1.9 最新五年平均 2 出版当年[2022版] 2.1 出版当年五年平均 2.116 出版前一年[2021版] 1.9 出版后一年[2023版]

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第一作者机构： [1]Department of Science and Education, First Affiliated Hospital of Kunming Medical University, Kunming, China

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通讯机构： [1]Department of Science and Education, First Affiliated Hospital of Kunming Medical University, Kunming, China [*1]295 Xi Chang Road, Kunming, China.

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