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Association of Paraspinal Muscle CSA and PDFF Measurements With Lumbar Intervertebral Disk Degeneration in Patients With Chronic Low Back Pain.

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收录情况： ◇ SCIE

作者：
Huang Yilong[1] ; Wang Ling[2] ; Zeng Xiaomin[1,3] ; Chen Jiaxin[1] ; Zhang Zhenguang[1] ; Jiang Yuanming[1] ; Nie Lisha[4] ; Cheng Xiaoguang[2] ; He Bo[1] ;
机构： [1]Department of Medical Imaging, the First Affiliated Hospital of Kunming Medical University, Kunming, China. [2]Department of Radiology, Beijing Jishuitan Hospital, Beijing, China. [3]GE Healthcare, Magnetic Resonance Field Application Team, Chengdu, China. [4]GE Healthcare, Magnetic Resonance Research China, Beijing, China.
出处：
DOI： 10.3389/fendo.2022.792819
ISSN：

关键词： chronic low back pain quantitative MRI paraspinal muscles fatty infiltration lumbar intervertebral disk degeneration

摘要：
There is an interaction between the lumbar spine and paraspinal muscles, which may play a role in the development of intervertebral disc (IVD) degeneration and may affect CLBP. The study aims to assess the relationship between IVD degeneration and paraspinal muscle fat infiltration in CLBP patients by quantitative MR imaging, and to evaluate the influence of sex and age on CLBP muscle fat infiltration. Sixty CLBP patients (46.3 years ±17.0) and thirty-two healthy subjects (44.9 years ±17.6) were recruited for this study. 3.0 T MRI was used to perform the sagittal and axial T1, T2 of the lumbar spine, and axial paraspinal muscle IDEAL imaging at the L4/5 and L5/S1 levels. Proton density fat fraction (PDFF) of the multifidus and erector spinae at two IVD levels were measured. The Pfirrmann grades of IVD degeneration, Oswestry Disability Index (ODI), and Visual Analog Scale (VAS) were also evaluated. Compare the cross-sectional area (CSA) and PDFF of the paraspinal muscles between CLBP patients and healthy subjects, and analyze the relationship between the muscle PDFF and Pfirrmann grades, gender, and age of CLBP patients. Compared with healthy subjects, the CSA of the multifidus muscle in CLBP patients decreased (1320.2±188.1mm2 vs. 1228.7±191.0 mm2, p<0.05) at the L4/5 level, the average PDFF increased, (7.7±2.6% vs. 14.79±5.3%, 8.8±4.2% vs. 16.03±5.3%, all p<0.05) at both L4/5 and L5/S1 levels. The PDFF of paraspinal muscles were correlated with adjacent IVD degeneration, ODI and VSA in CLBP patients (all p<0.05). After using age and body mass index (BMI) as control variables, significance was retained (all p<0.05). Multiple regression analysis revealed sex and age also were significantly associated with multifidus PDFF (all p < 0.05). This study confirmed that the CSA decreased and the PDFF increased of the paraspinal muscles in CLBP patients. It reveals a significant correlation between the PDFF of CLBP paraspinal muscles and the grade of IVD degeneration. Sex and age are also important factors influencing CLBP paraspinal muscle infiltration.Copyright © 2022 Huang, Wang, Zeng, Chen, Zhang, Jiang, Nie, Cheng and He.

基金：
This work is supported by the Applied Basic Research Project of Yunnan Province- Kunming Medical University Joint Fund (202001AY070001-038), Beijing Hospitals Authority Youth Programme (QMS20200402), and Yunnan Provincial Bone and Joint Disease Clinical Medicine Center Project (ZX2019- 03-04).
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢
JCR分区：
出版当年[2022]版：
Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q2 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Medical Imaging, the First Affiliated Hospital of Kunming Medical University, Kunming, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Huang Yilong,Wang Ling,Zeng Xiaomin,et al.Association of Paraspinal Muscle CSA and PDFF Measurements With Lumbar Intervertebral Disk Degeneration in Patients With Chronic Low Back Pain.[J].FRONTIERS IN ENDOCRINOLOGY.2022,13:792819.doi:10.3389/fendo.2022.792819.
APA：
Huang Yilong,Wang Ling,Zeng Xiaomin,Chen Jiaxin,Zhang Zhenguang...&He Bo.(2022).Association of Paraspinal Muscle CSA and PDFF Measurements With Lumbar Intervertebral Disk Degeneration in Patients With Chronic Low Back Pain..FRONTIERS IN ENDOCRINOLOGY,13,
MLA：
Huang Yilong,et al."Association of Paraspinal Muscle CSA and PDFF Measurements With Lumbar Intervertebral Disk Degeneration in Patients With Chronic Low Back Pain.".FRONTIERS IN ENDOCRINOLOGY 13.(2022):792819

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