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Association Between Fat Mass to Lean Body Mass Ratio and All-Cause Mortality Among Middle-Aged and Elderly Cancer Patients Without Obesity: A Multi-Center Observational Study in China

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收录情况： ◇ SCIE

作者：
Xue, Hongmei[1,2] * ; Du, Hongzhen[1,2] * ; Xie, Ying[1,2] ; Zhai, Yijing[1,2] ; Song, Shiming[1,2] ; Luo, Bin[1,2] ; Qiu, Hong[3] ; Wang, Kunhua[4] ; Cui, Jiuwei[5] ; Song, Chunhua[6] ; Xu, Hongxia[7] ; Li, Wei[5] ; Shi, Hanping[8,9] ; Li, Zengning[1,2] ; The Investigation on Nutrition Status and Its Clinical Outcome of Common Cancers (INSCOC)[INSCOC] ;
机构： [1]Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China, [2]Hebei Province Key Laboratory of Nutrition and Health, Shijiazhuang, China, [3]Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, [4]Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China, [5]Cancer Center, The First Hospital of Jilin University, Changchun, China, [6]Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China, [7]Department of Nutrition, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China, [8]Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China, [9]Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Chinese Society of Nutritional Oncology, Beijing, China
出处：
DOI： 10.3389/fnut.2022.914020
ISSN：

关键词： fat mass to lean body mass ratio percentage of body fat fat mass all-cause mortality elderly cancer patients

摘要：
ObjectiveWe aimed to investigate the association between fat mass to lean body mass ratio (RFL), percentage of body fat (PBF), and fat mass (FM) with mortality among middle-aged and elderly cancer patients without obesity. MethodsThis prospective hospital-based cohort study comprised 3,201 patients with stage I to IV cancer aged 40 years or above (mean age: 58 years for female patients and 61 years for male patients; mean length of follow-up was 1.67 years; the maximal follow-up length was 6.42 years). FM and PBF were measured by bioelectrical impedance analysis (BIA). Cox proportional hazard models were used, and adjusted hazard ratios (HRs) were estimated. ResultsWe revealed a significant association between RFL and all-cause mortality among men aged >= 60 years after adjusting for confounders. Compared with those in the lowest tertile of RFL, elderly men in the medium and highest tertile had a 35 and 34% lower hazard of death from any cause, respectively. After additionally adjusted for C-reaction protein (CRP), HRs of medium and high tertile of RFL became short of statistical significance [medium tertile: adjusted HRs (95% CI) = 0.74 (0.46, 1.20); highest tertile: adjusted HRs (95% CI) = 0.84 (0.53, 1.33)]. Among elderly women, RFL was significantly related to all-cause mortality only when the additional adjustment for CRP [medium tertile: adjusted HRs (95% CI) = 2.08 (1.08, 4.01); highest tertile: adjusted HRs (95% CI) = 0.90 (0.45, 1.81)]. No significant association between RFL and all-cause mortality was observed among female participants or male participants aged less than 60 years. ConclusionOur findings showed a significant non-linear association between RFL and all-cause mortality, which was observed only in elderly men, and might be attenuated by their inflammation state.

基金：
Key Development and Research Program of Hebei Province, China, grant number 21377728D and the Chinese Association of Geriatric Research, grant number HZ202102.
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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 农林科学
小类 | 3 区 营养学
最新[2025]版：
大类 | 2 区 农林科学
小类 | 3 区 营养学
JCR分区：
出版当年[2022]版：
Q2 NUTRITION & DIETETICS
最新[2023]版：
Q2 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China, [2]Hebei Province Key Laboratory of Nutrition and Health, Shijiazhuang, China,
共同第一作者：
通讯作者：
通讯机构： [1]Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China, [2]Hebei Province Key Laboratory of Nutrition and Health, Shijiazhuang, China, [8]Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China, [9]Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Chinese Society of Nutritional Oncology, Beijing, China
推荐引用方式(GB/T 7714)：
Xue Hongmei,Du Hongzhen,Xie Ying,et al.Association Between Fat Mass to Lean Body Mass Ratio and All-Cause Mortality Among Middle-Aged and Elderly Cancer Patients Without Obesity: A Multi-Center Observational Study in China[J].FRONTIERS IN NUTRITION.2022,9:doi:10.3389/fnut.2022.914020.
APA：
Xue, Hongmei,Du, Hongzhen,Xie, Ying,Zhai, Yijing,Song, Shiming...&The Investigation on Nutrition Status and Its Clinical Outcome of Common Cancers (INSCOC).(2022).Association Between Fat Mass to Lean Body Mass Ratio and All-Cause Mortality Among Middle-Aged and Elderly Cancer Patients Without Obesity: A Multi-Center Observational Study in China.FRONTIERS IN NUTRITION,9,
MLA：
Xue, Hongmei,et al."Association Between Fat Mass to Lean Body Mass Ratio and All-Cause Mortality Among Middle-Aged and Elderly Cancer Patients Without Obesity: A Multi-Center Observational Study in China".FRONTIERS IN NUTRITION 9.(2022)

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