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The Role of SliTrk5 in Central Nervous System

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机构： [1]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China [2]Yunnan Provincial Clinical Research Center for Neurological Disease, Kunming, Yunnan 650032, China [3]Department of Neurology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650034, China

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SLIT and NTRK-like protein-5 (SliTrk5) is one of the six members of SliTrk protein family, which is widely expressed in the central nervous system (CNS), regulating and participating in many essential steps of central nervous system development, including axon and dendritic growth, neuron differentiation, and synaptogenesis. SliTrk5, as a neuron transmembrane protein, contains two important conservative domains consisting of leucine repeats (LRRs) located at the amino terminal in the extracellular region and tyrosine residues (Tyr) located at the carboxyl terminal in the intracellular domains. These special structures make SliTrk5 play an important role in the pathological process of the CNS. A large number of studies have shown that SliTrk5 may be involved in the pathogenesis of CNS diseases, such as obsessive-compulsive-disorder (OCD), attention deficit/hyperactivity disorder (ADHD), glioma, autism spectrum disorders (ASDs), and Parkinson's disease (PD). Targeting SliTrk5 is expected to become a new target for the treatment of CNS diseases, promoting the functional recovery of CNS. The purpose of this article is to review the current research progression of the role of SliTrk5 in CNS and its potential mechanisms in CNS diseases.Copyright © 2022 Yan Liu et al.

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最新[2023]版：

Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.6 最新[2023版] 3.1 最新五年平均 0 出版当年[2022版] 0 出版当年五年平均 3.246 出版前一年[2021版] 2.6 出版后一年[2023版]

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第一作者机构： [1]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China

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通讯机构： [1]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China [2]Yunnan Provincial Clinical Research Center for Neurological Disease, Kunming, Yunnan 650032, China [3]Department of Neurology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650034, China

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