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Crosstalk between the liver and kidney in diabetic nephropathy

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收录情况： ◇ SCIE

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机构： [1]Department of Nutrition, Xiangya Hospital, Central South University, Changsha, Hunan, China [2]Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China [3]Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, China [4]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Diabetic nephropathy (DN) is a serious complication of diabetes, and its pathogenesis has not been fully elucidated. Recently, communication between organs has gradually become a new focus in the study of diseases pathogenesis, and abnormal interorgan communication has been proven to be involved in the occurrence and progression of many diseases. As an important metabolic organ in the human body, the liver plays an important role in maintaining homeostasis in humans. The liver secretes a series of proteins called hepatokines that affect adjacent and distal organs through paracrine or endocrine signaling pathways. In this review, we summarize some of the hepatokines identified to date and describe their roles in DN to discuss the possibility that the liver-renal axis is potentially useful as a therapeutic target for DN. We summarize the important hepatokines identified thus far and discuss their relationship with DN. We propose for the first time that the "liver-renal axis" is a potential therapeutic target in individuals with DN.Copyright © 2022. Published by Elsevier B.V.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 2 区药学

最新[2023]版：

大类 | 3 区医学

小类 | 2 区药学

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出版当年[2022]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.2 最新[2023版] 4.3 最新五年平均 5 出版当年[2022版] 4.6 出版当年五年平均 5.195 出版前一年[2021版] 4.2 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Nutrition, Xiangya Hospital, Central South University, Changsha, Hunan, China [2]Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China

通讯作者：

通讯机构： [1]Department of Nutrition, Xiangya Hospital, Central South University, Changsha, Hunan, China [4]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China [*1]Department of Nutrition, Xiangya Hospital, Central South University, Changsha, Hunan, China

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