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Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo

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机构: [1]Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming, 650091, P. R. China. gaofeng@ynu.edu.cn. [2]Animal Research and Resource Center, School of Life Sciences, Yunnan University, Kunming, 650091, P. R. China. [3]First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China.
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Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as an antitumor photothermal therapy agent in vitro and in vivo.

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出版当年[2023]版:
大类 | 2 区 化学
小类 | 3 区 化学:综合
最新[2023]版:
大类 | 2 区 化学
小类 | 3 区 化学:综合
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出版当年[2022]版:
Q2 CHEMISTRY, MULTIDISCIPLINARY
最新[2023]版:
Q2 CHEMISTRY, MULTIDISCIPLINARY

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第一作者机构: [1]Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming, 650091, P. R. China. gaofeng@ynu.edu.cn.
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