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Identification and Verification of Ubiquitin D as a Gene Associated with Hepatitis C Virus-Induced Hepatocellular Carcinoma

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机构： [1]Department of Clinical Laboratory, First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, China. [2]Department of Clinical Laboratory, First Affiliated Hospital of Kunming Medical University, Kunming, China. [3]Yunnan Key Laboratory of Laboratory Medicine, Kunming, China. [4]Yunnan Innovation Team of Clinical Laboratory and Diagnosis, First Affiliated Hospital of Kunming Medical University, Kunming, China.

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Accumulated studies have suggested that hepatitis C virus (HCV) infection is one of the leading causes for hepatocellular carcinoma (HCC). However, the mechanisms underlying the effect of HCV on the occurrence of HCC are still poorly understood.HCV infection datasets (GSE82177 and GSE17856) and HCC datasets (The Cancer Genome Atlas Liver Hepatocellular Carcinoma and GSE89377) were downloaded from Gene Expression Omnibus or TCGA for analysis. The common differentially expressed genes in the above four datasets were identified by R software. The expression of ubiquitin D (UBD) in HCV-infected HepG2 cells was detected by RT-qPCR and Western blot, respectively. The interaction between NS3 and p53 was detected by co-immunoprecipitation. The influence of UBD on the proliferation and migration ability of HepG2 cells was evaluated by CCK-8 and wound healing assay, respectively.UBD was upregulated in both HCV-infected samples and HCC samples. HCV NS3 interacted with p53 and inhibited its expression. HCV NS3-induced UBD promoted the proliferation and migration of HepG2 cells.Our results suggest that HCV NS3-induced UBD is positively correlated with the development of HCV-related HCC during HCV infection. Targeting UBD could be a potential strategy for preventing and treating HCV-induced HCC.© 2022 The Author(s). Published by S. Karger AG, Basel.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区病毒学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区病毒学

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出版当年[2022]版：

Q2 VIROLOGY

最新[2023]版：

Q3 VIROLOGY

影响因子： 3.2 最新[2023版] 2.5 最新五年平均 4.6 出版当年[2022版] 2.8 出版当年五年平均 2.294 出版前一年[2021版] 3.2 出版后一年[2023版]

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第一作者机构： [1]Department of Clinical Laboratory, First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, China.

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通讯机构： [2]Department of Clinical Laboratory, First Affiliated Hospital of Kunming Medical University, Kunming, China. [3]Yunnan Key Laboratory of Laboratory Medicine, Kunming, China. [4]Yunnan Innovation Team of Clinical Laboratory and Diagnosis, First Affiliated Hospital of Kunming Medical University, Kunming, China.

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