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Relevance of the pyroptosis-related inflammasome drug targets in the Chuanxiong to improve diabetic nephropathy

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机构： [1]Department of Nephrology, The First Afliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming 650032, Yunnan, China [2]Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA 92521, USA [3]Kunming Medical University, Kunming 650500, Yunnan, China [4]Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.

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A chronic inflammatory disease caused by disturbances in metabolism, diabetic nephropathy (DN) is a chronic inflammatory disease. Pyroptosis is a novel form of programmed cell death in many inflammation-related diseases, including DN. Therefore, pyroptosis could be a promising target for DN therapy.To get the components and pharmacodynamic targets of Chuanxiong, we identified by searching TCMID, TCMSP, ETCM and HERB databases. Then, from the Molecular Signatures Database (MSigDB) and Gene Ontology (GO) database, pyroptosis genes were collected. Identification of critical genes in DN by bioinformatics analysis and then using the ConsensusClusterPlus package to divide the express data of diff genes into some subgroups with different levels of pyroptosis; the WGCNA machine algorithm was used to simulate the mechanism Chuanxiong improving DN.In this study, we found DHCR24, ANXA1, HMOX1, CDH13, ALDH1A1, LTF, CHI3L1, CACNB2, and MTHFD2 interacted with the diff genes of DN. We used GSE96804 as a validation set to evaluate the changes of APIP, CASP6, CHMP2B, CYCS, DPP8, and TP53 in four different cell proapoptotic states. WGCNA analysis showed that DHCR24, CHI3L1, and CACNB2 had significant changes in different cell proapoptotic levels. In the experimental stage, we also confirmed that the active ingredients of Chuanxiong could improve the inflammatory state and the levels of pyroptosis under high glucose.The improvement of DN by Chuanxiong is related to the change of pyroptosis.© 2022. The Author(s).

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区细胞生物学 2 区医学：研究与实验

最新[2023]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区细胞生物学 2 区医学：研究与实验

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出版当年[2022]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 6 最新[2023版] 6 最新五年平均 5.7 出版当年[2022版] 6.3 出版当年五年平均 6.382 出版前一年[2021版] 6 出版后一年[2023版]

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第一作者机构： [1]Department of Nephrology, The First Afliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming 650032, Yunnan, China

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