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1,25(OH)2D3 alleviates LPS-induced preeclampsia-like rats impairment in the protective effect by TLR4/NF-kB pathway

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机构： [1]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China [2]Yunnan Key Laboratory of Laboratory Medicine, Kunming, China [3]Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China [4]Department of Medical Genetics and Prenatal Diagnosis, Kunming Maternal and Child Health Hospital Kunming, China [5]Department of Reproduction, The First People’s Hospital of Puer City, Puer, China [6]Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China

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Accumulating epidemiological studies support that Vitamin D deficiency is associated with the pathogenesis of preeclampsia. However, it is unknown whether vitamin D can be used as a treatment for preeclampsia. This study aimed to explore whether vitamin D supplementation could improve the rat model of preeclampsia.LPS was used to establish a rat model of preeclampsia. Inflammatory cytokines were examined by QRT-PCR and ELISA assays, and the concentration of sfit-1 and NO was assessed by ELISA. Analyzing the pathological features of the placenta with hematoxylin-eosin. The spatial learning and memory abilities of offspring were evaluated by the Morris water maze. Immune histology and western blot were performed to evaluate the expression levels of inflammatory pathway-associated Factor and vascular endothelium-associated Factor in the placenta.Vitamin D treatment reduced the blood pressure and urine protein of PE model rats, alleviated pathological damage to the placenta and pregnancy outcomes, and protected PE offspring from impaired memory and learning abilities. Moreover, TLR4 signaling pathway in the placenta was inhibited. Furthermore, vitamin D supplementation increased the expression of endothelial growth factor and vascular relaxing factor, and there was no significant difference compared with the control group.We generated the result that Vitamin D supplementation significantly improved the phenotype of preeclampsia and adverse pregnancy outcome caused by an abnormal inflammatory reaction and endothelial dysfunction in the placenta, and improved the learning and cognitive ability of offspring.Copyright © 2022. Published by Elsevier Ltd.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区发育生物学 2 区妇产科学 2 区生殖生物学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区发育生物学 2 区妇产科学 2 区生殖生物学

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出版当年[2022]版：

Q2 DEVELOPMENTAL BIOLOGY Q2 OBSTETRICS & GYNECOLOGY Q2 REPRODUCTIVE BIOLOGY

最新[2023]版：

Q1 OBSTETRICS & GYNECOLOGY Q2 DEVELOPMENTAL BIOLOGY Q2 REPRODUCTIVE BIOLOGY

影响因子： 3 最新[2023版] 3.1 最新五年平均 3.8 出版当年[2022版] 3.8 出版当年五年平均 3.287 出版前一年[2021版] 3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China [2]Yunnan Key Laboratory of Laboratory Medicine, Kunming, China

通讯作者：

通讯机构： [1]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China [2]Yunnan Key Laboratory of Laboratory Medicine, Kunming, China [3]Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, China [4]Department of Medical Genetics and Prenatal Diagnosis, Kunming Maternal and Child Health Hospital Kunming, China [*1]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

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