机构：[1]The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.[2]The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.昆明医科大学附属第一医院神经内科内科科室[3]Center for Neurological Function Test and Neuromodulation, West China Xiamen Hospital, Sichuan University, Chengdu, Sichuan, China.[4]Affiliated Mental Health Center of Kunming Medical University, Kunming, Yunnan, China.
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摘要：
Human beings develop a highly coordinated and flexible system of social behavior and threat evaluation. In this review we focus on the unique role of early life adversity (ELA) in programming deficits in social behavior and threat processing, and provides guidance on future investigations in the areas of stress reactivity and mental health. We propose that neuroendocrine perturbations of hypothalamus-pituitary-adrenal (HPA) axis and gene activity by epigenetic mechanisms may explain how early adverse circumstances may lead to post traumatic stress disorder (PTSD). The detailed exploration of the interaction of stress as environmental factor and epigenetic and genetic regulation in HPA axis may improve targeted interventions among vulnerable individuals. We are convinced that further studies following these directions will contribute to effective prevention and treatment of PTSD in early traumatized patients.
第一作者机构：[1]The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
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推荐引用方式(GB/T 7714)：
Wang Weiwei,Liu Xiaolei,Huang Jiaxi,et al.The Connection of Early Life Adversity and Post Traumatic Stress Disorder: an Updated Review[J].DISCOVERY MEDICINE.2022,34(171):25-32.
APA：
Wang Weiwei,Liu Xiaolei,Huang Jiaxi,Zeng Shue,Bao Jianjun...&Bao Tianhao.(2022).The Connection of Early Life Adversity and Post Traumatic Stress Disorder: an Updated Review.DISCOVERY MEDICINE,34,(171)
MLA：
Wang Weiwei,et al."The Connection of Early Life Adversity and Post Traumatic Stress Disorder: an Updated Review".DISCOVERY MEDICINE 34..171(2022):25-32
