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Generation of a human iPSC line (CIBi013-A) from a patient with young-onset Parkinson's disease carrying a novel homozygous PARK7 (DJ-1) mutation

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机构: [1]Department of Neurology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. [2]Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China. [3]Department of Neurology, The Third People's Hospital of Henan Province, Zhengzhou 450000, China. [4]Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd, Shenzhen 518101, China. [5]Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. [6]Division of Neurology, Department of Medicine, University of Hong Kong, Hong Kong. [7]The 1st School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China. [8]Department of Anesthesiology and Pain, The Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang, China. [9]Department of Neurology, First Affiliated Hospital of Kunming Medical University, No.1 School of Clinical Medicine, Kunming Medical University, Kunming 650500, China. [10]School of Rehabilitation, Kunming Medical University, Kunming 650500, China.
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Mutations in PARK7 and the resulting alterations in its production protein (DJ-1) are tightly associated with Parkinson's disease. We generated a human induced pluripotent stem cell (iPSC) line (CIBi013-A) from a patient with young-onset Parkinson's disease (YOPD) who carried a novel homozygous PARK7 (DJ-1) mutation (chr1:8037723, c.334C>G). The generated iPSCs will be used for investigating phenotype and underlying molecular mechanisms in patient-derived cells.Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

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大类 | 4 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 细胞与组织工程 4 区 细胞生物学
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出版当年[2023]版:
Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY
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Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

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第一作者机构: [1]Department of Neurology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China.
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