机构：[1]Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China[2]Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, Henan, China[3]Department of Clinical Nutrition, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China[4]Cancer Center of the First Hospital of Jilin University, Changchun, China[5]Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China内科科室外科科室消化内科普通外科普通外一科(胃肠与疝外科)昆明医科大学附属第一医院[6]Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院[7]Department of Gastrointestinal Surgery and Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China[8]State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China
Low phase angle (PhA) is related with poor clinical status of cancer patients. The objective of this study was to establish sex- and age-specific cutoff points and examine the association between PhA and overall survival (OS) in Chinese cancer patients. This cohort study included data on 1,814 patients with cancer from December 2013 to October 2020. The association between low PhA and overall survival was analyzed using the Kaplan-Meier method and Cox regression model. Among 1,814 participants, there were 993 (54.70%) male and 821 (45.30%) female patients. The optimal cutoff points of low PhA were 4.8 degrees, 4.2 degrees, 4.4 degrees, and 3.8 degrees for the young male, elderly male, young female, and elderly female, respectively. Low PhA was independently associated with poorer OS in young female, elderly female and male (HR: 1.59, 95% CI: 1.08-2.34; HR: 1.65, 95% CI: 1.03-2.67; HR: 2.00, 95% CI: 1.45-2.75). In addition, low PhA was demonstrated to be an adverse prognostic factor in patients with lung cancer, colorectal cancer, and esophagus cancer (HR: 1.85, 95% CI: 1.39-2.47; HR: 2.05, 95% CI: 1.13-3.70; HR: 2.92, 95% CI: 1.49-5.71). Based on cutoff points, low PhA was associated with worse prognosis in patients with cancer.
基金：
This work was supported by the National Key Research and
Development Program under Grant number
2017YFC1309200; and Henan University Science and
Technology Innovation Talents Support Program under
Grant number 19HASTIT005.
第一作者机构：[1]Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China[2]Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, Henan, China
通讯作者：
通讯机构：[1]Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China[2]Henan Key Laboratory of Tumor Epidemiology, Zhengzhou University, Zhengzhou, Henan, China[8]State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China[*1]Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, China
推荐引用方式(GB/T 7714)：
Zou Yuanlin,Xu Hongxia,Cui Jiuwei,et al.Association of Phase Angle with Overall Survival in Patients with Cancer: A Prospective Multicenter Cohort Study[J].NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL.2023,75(3):890-900.doi:10.1080/01635581.2023.2165693.
APA：
Zou, Yuanlin,Xu, Hongxia,Cui, Jiuwei,Wang, Kunhua,Feng, Yongdong...&Song, Chunhua.(2023).Association of Phase Angle with Overall Survival in Patients with Cancer: A Prospective Multicenter Cohort Study.NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,75,(3)
MLA：
Zou, Yuanlin,et al."Association of Phase Angle with Overall Survival in Patients with Cancer: A Prospective Multicenter Cohort Study".NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 75..3(2023):890-900
