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Hemoglobin A1c in type 2 diabetes mellitus patients with preserved ejection fraction is an independent predictor of left ventricular myocardial deformation and tissue abnormalities

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机构: [1]Department of Radiology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, China. [2]Department of General Medicine, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, China. [3]Department of Radiology, First People’s Hospital of Honghe State, 1 Xiyuan Road, Honghe 661100, China.
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关键词: Type 2 diabetes mellitus Hypertension Cardiac magnetic resonance T1 mapping Feature tracking Hemoglobin A1c

摘要:
 Early detection of subclinical myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM) is essential for preventing heart failure. This study aims to search for predictors of left ventricular (LV) myocardial deformation and tissue abnormalities in T2DM patients with preserved ejection fraction by using CMR T1 mapping and feature tracking. 70 patients and 44 sex- and age-matched controls (Cs) were recruited and underwent CMR examination to obtain LV myocardial extracellular volume fraction (ECV) and global longitudinal strain (GLS). The patients were subdivided into three groups, including 19 normotensive T2DM patients (G1), 19 hypertensive T2DM patients (G2) and 32 hypertensive patients (HT). The baseline biochemical indices were collected before CMR examination. LV ECV in T2DM patients was significantly higher than that in Cs (30.75 ± 3.65% vs. 26.33 ± 2.81%; p < 0.05). LV GLS in T2DM patients reduced compared with that in Cs (-16.51 ± 2.53% vs. -19.66 ± 3.21%, p < 0.001). In the subgroup analysis, ECV in G2 increased compared with that in G1 (31.92 ± 3.05% vs. 29.59 ± 3.90%, p = 0.032) and that in HT, too (31.92 ± 3.05% vs. 29.22 ± 6.58%, p = 0.042). GLS in G2 significantly reduced compared with that in G1 (-15.75 ± 2.29% vs. -17.27 ± 2.57%, p < 0.05) and in HT, too (-15.75 ± 2.29% vs. -17.54 ± 3.097%, p < 0.05). In T2DM group, including both G1 and G2, hemoglobin A1c (HbA1c) can independently forecast the increase in ECV (β = 0.274, p = 0.001) and decrease in GLS (β = 0.383, p = 0.018).T2DM patients with preserved ejection fraction show increased ECV but deteriorated GLS, which may be exacerbated by hypertension of these patients. Hemoglobin A1c is an index that can independently predict T2DM patients' LV myocardial deformation and tissue abnormalities.© 2023. The Author(s).

基金:

基金编号: 82060312 60118090127] and Miss Zhiming Li’s Graduate Innovation Fund of Kunming Medical University [2021S185

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大类 | 3 区 医学
小类 | 4 区 心脏和心血管系统
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出版当年[2023]版:
Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
最新[2023]版:
Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

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第一作者机构: [1]Department of Radiology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, China.
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