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Random and aligned electrostatically spun PLLA nanofibrous membranes enhance bone repair in mouse femur midshaft defects

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机构： [1]Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, China. [2]The Basic Medical School of Kunming Medical University, Kunming, China. [3]Outpatient Department, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. [4]The First Clinical College of Kunming Medical University, Kunming, China. [5]Yunnan Provincial Clinical Medical for Bone and Joint Diseases, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

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Long-segment bone defects are a common clinical challenge and abstract biomaterials are a promising therapy. Poly-L-lactic acid (PLLA) nanofibrous membranes prepared by electrostatic spinning have a good bone repair potential. However, there are random and aligned surface morphologies of electrostatic spun PLLA nanofibrous membranes, which can affect the migration, proliferation, and differentiation ability of cells. The role of surface morphology in the repair of long bone defects in vivo is currently unknown. In this study, random and aligned electrostatically spun PLLA nanofibrous membranes were prepared, characterised, and implanted into a femur midshaft defect mouse model. The ability of electrostatically spun PLLA nanofibrous membranes to enhance bone repair was tested using X-ray photography, high-resolution micro-computed tomography (micro-CT), and pathological section specimens. The results showed that both random and aligned electrostatically spun PLLA nanofibrous membranes enhanced bone regeneration at bone defects, but the aligned ones exhibited superior results. These results provide a theoretical basis for engineering the surface morphology of bone repair materials.

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最新[2023]版：

大类 | 4 区医学

小类 | 4 区工程：生物医学 4 区材料科学：生物材料

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出版当年[2023]版：

Q3 ENGINEERING, BIOMEDICAL Q4 MATERIALS SCIENCE, BIOMATERIALS

最新[2023]版：

Q3 ENGINEERING, BIOMEDICAL Q4 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 2.3 最新[2023版] 2.7 最新五年平均 2.3 出版当年[2023版] 2.7 出版当年五年平均 2.9 出版前一年[2022版]

第一作者：

第一作者机构： [1]Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, China. [2]The Basic Medical School of Kunming Medical University, Kunming, China.

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通讯作者：

通讯机构： [1]Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, China. [5]Yunnan Provincial Clinical Medical for Bone and Joint Diseases, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

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