Ferroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative stress and cell death. Iron, lipid, and multiple signaling pathways precisely control the occurrence and implementation of ferroptosis. The pathways mainly include Nrf2/HO-1 signaling pathway, p62/Keap1/Nrf2 signaling pathway. Activating p62/Keap1/Nrf2 signaling pathway inhibits ferroptosis. Nrf2/HO-1 signaling pathway promotes ferroptosis. Furthermore, some factors also participate in the occurrence of ferroptosis under hypoxia, such as HIF-1, NCOA4, DMT1. Meanwhile, ferroptosis is related with hypoxia-related diseases, such as MIRI, cancers, and AKI. Accordingly, ferroptosis appears to be a therapeutic target for hypoxia-related diseases.
基金：
The present study was funded by the National Natural Science Foundation of China (No.82160007) and the Yunnan Provincial
Science and Technology Department [Nos. 2019FE001 (-058)].
第一作者机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, 295 Xichang Rd, Kunming 650032, Peoples R China[2]Kunming Med Univ, 2020 Clin Med Class 6, Kunming 650500, Peoples R China
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通讯作者：
推荐引用方式(GB/T 7714)：
Gao Xin,Hu Wei,Qian Dianlun,et al.The Mechanisms of Ferroptosis Under Hypoxia[J].CELLULAR AND MOLECULAR NEUROBIOLOGY.2023,43(7):3329-3341.doi:10.1007/s10571-023-01388-8.
APA：
Gao, Xin,Hu, Wei,Qian, Dianlun,Bai, Xiangfeng,He, Huilin...&Sun, Shibo.(2023).The Mechanisms of Ferroptosis Under Hypoxia.CELLULAR AND MOLECULAR NEUROBIOLOGY,43,(7)
MLA：
Gao, Xin,et al."The Mechanisms of Ferroptosis Under Hypoxia".CELLULAR AND MOLECULAR NEUROBIOLOGY 43..7(2023):3329-3341
