BackgroundWhereas the Montreal Cognitive Assessment (MoCA) and Addenbrooke's cognitive examination-revised (ACE-R) are commonly used tests for the detection of post-stroke cognitive impairment (PSCI), these instruments take 10-30 min to administer and do not assess processing speed, which is a critical impairment in PSCI. MemTrax (MTx) is a continuous recognition test, which evaluates complex information processing, accuracy, speed, and attention, in 2 min. AimTo evaluate whether MTx is an effective and practical tool for PSCI assessment. MethodsThis study enrolled acute ischemic stroke (AIS) patients who have assessed the cognitive status including MTx, clinical dementia rating (CDR), MoCA, Neuropsychiatric Inventory (NPI), Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), the National Institute of Health Stroke Scale (NIHSS), modified Rankin scale (mRS), and Barthel Index of activity of daily living (BI) combined with the physical examinations of the neurologic system at the 90-day (D90) after the AIS. The primary endpoint of this study was establishing MTx cut-offs for distinguishing PSCI from AIS. ResultsOf the 104 participants, 60 were classified to the PSCI group. The optimized cut-off value of MTx-%C (percent correct) was 78%, with a sensitivity and specificity for detecting PSCI from Non-PSCI of 90.0 and 84.1%, respectively, and an AUC of 0.919. Regarding the MTx-Cp (Composite score = MTx-%C/MTx-RT), using 46.3 as a cut-off value, the sensitivity and specificity for detecting PSCI from Non-PSCI were 80.0 and 93.2%, with an AUC of 0.925. Multivariate linear regression showed that PSCI reduced the MTx-%C (Coef. -14.18, 95% CI -18.41 & SIM;-9.95, p < 0.001) and prolonged the MTx-RT (response time) (Coef. 0.29, 95% CI 0.16 & SIM;0.43, p < 0.001) and reduced the MTx-CP (Coef. -19.11, 95% CI -24.29 & SIM;-13.93, p < 0.001). ConclusionMemTrax (MTx) is valid and effective for screening for PSCI among target patients and is a potentially valuable and practical tool in the clinical follow-up, monitoring, and case management of PSCI.
第一作者机构:[1]Kunming Med Univ, Affiliated Hosp 1, Dept Neurol, Kunming, Peoples R China[2]Yunnan Prov Clin Res Ctr Neurol Dis, Kunming, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Kunming Med Univ, Affiliated Hosp 1, Dept Neurol, Kunming, Peoples R China[2]Yunnan Prov Clin Res Ctr Neurol Dis, Kunming, Peoples R China[10]VA Palo Alto Hlth Care Syst HCS, War Related Illness & Injury Study Ctr, Palo Alto, CA 94304 USA[11]Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
推荐引用方式(GB/T 7714):
Zhao Xiaoxiao,Dai Shujuan,Zhang Rong,et al.Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study[J].FRONTIERS IN HUMAN NEUROSCIENCE.2023,17:doi:10.3389/fnhum.2023.1195220.
APA:
Zhao, Xiaoxiao,Dai, Shujuan,Zhang, Rong,Chen, Xinjie,Zhao, Mingjie...&Liu, Xiaolei.(2023).Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study.FRONTIERS IN HUMAN NEUROSCIENCE,17,
MLA:
Zhao, Xiaoxiao,et al."Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study".FRONTIERS IN HUMAN NEUROSCIENCE 17.(2023)