Protective factors for children with autism spectrum disorder during COVID-19-related strict lockdowns: a Shanghai autism early developmental cohort study
机构：[1]Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Psychology and Neuroscience of Cognition Research Unit, University of Liège, Liège, Belgium[3]Center for Experimental Studies and Research, The First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院[4]Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China[5]Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China[6]Psychiatry Department of Huashan Hospital, Fudan University, Shanghai, China[7]Department of Psychiatry and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK[8]National Clinical Research Center for Aging and Medicine at Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433,China[9]MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Institutes of Brain Science and Human Phenome Institute, Fudan University, Shanghai 200032, China
COVID-19 lockdowns increased the risk of mental health problems, especially for children with autism spectrum disorder (ASD). However, despite its importance, little is known about the protective factors for ASD children during the lockdowns.Based on the Shanghai Autism Early Developmental Cohort, 188 ASD children with two visits before and after the strict Omicron lockdown were included; 85 children were lockdown-free, while 52 and 51 children were under the longer and the shorter durations of strict lockdown, respectively. We tested the association of the lockdown group with the clinical improvement and also the modulation effects of parent/family-related factors on this association by linear regression/mixed-effect models. Within the social brain structures, we examined the voxel-wise interaction between the grey matter volume and the identified modulation effects.Compared with the lockdown-free group, the ASD children experienced the longer duration of strict lockdown had less clinical improvement (β = 0.49, 95% confidence interval (CI) [0.19-0.79], p = 0.001) and this difference was greatest for social cognition (2.62 [0.94-4.30], p = 0.002). We found that this association was modulated by parental agreeableness in a protective way (-0.11 [-0.17 to -0.05], p = 0.002). This protective effect was enhanced in the ASD children with larger grey matter volumes in the brain's mentalizing network, including the temporal pole, the medial superior frontal gyrus, and the superior temporal gyrus.This longitudinal neuroimaging cohort study identified that the parental agreeableness interacting with the ASD children's social brain development reduced the negative impact on clinical symptoms during the strict lockdown.
基金：
National
Natural Science Foundation of China(Nos 82125032, 81930095, and
81761128035 to F. L.; 81873909 to Q. L.; 82001771 to L. Z.; 82204064 to
H. H.), the National Key Research and Development Program of China (No.
2019YFA0709502), the Science and Technology Commission of Shanghai
Municipality (Nos 19410713500 and 2018SHZDZX01 to F. L.;
20ZR1404900, 20DZ2260300, 23XD1423400, and 20JC1413400 to Q. L.),
the Shanghai Municipal Commission of Health and Family Planning (Nos
GWV-10.1-XK07, 2020CXJQ01, 2018YJRC03 to F. L.; 20214Y0125 to L. Z.),
the Shanghai Clinical Key Subject Construction Project (No. shslczdzk02902
to F. L.), the Shanghai Municipal Science and Technology Major Project
(Nos: 2018SHZDZX01 and 2021SHZDZX0103 to Q. L.), the Guangdong
Key Project (No. 2018B030335001 to F. L.), and innovative research team of
high-level local universities in Shanghai (No. SHSMU-ZDCX20211100 to
F. L.), the Shanghai Pujiang Program (No. 22PJD045 to H. H.) and the
Fundamental Research Funds for the Central Universities (to Q. L.).
第一作者机构：[1]Department of Developmental and Behavioral Pediatric and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[8]National Clinical Research Center for Aging and Medicine at Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433,China[9]MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Institutes of Brain Science and Human Phenome Institute, Fudan University, Shanghai 200032, China
推荐引用方式(GB/T 7714)：
Zhang Lingli,Ren Tai,He Hua,et al.Protective factors for children with autism spectrum disorder during COVID-19-related strict lockdowns: a Shanghai autism early developmental cohort study[J].PSYCHOLOGICAL MEDICINE.2024,54(6):1102-1112.doi:10.1017/S0033291723002908.
APA：
Zhang Lingli,Ren Tai,He Hua,Huang Like,Huang Runqi...&Li Fei.(2024).Protective factors for children with autism spectrum disorder during COVID-19-related strict lockdowns: a Shanghai autism early developmental cohort study.PSYCHOLOGICAL MEDICINE,54,(6)
MLA：
Zhang Lingli,et al."Protective factors for children with autism spectrum disorder during COVID-19-related strict lockdowns: a Shanghai autism early developmental cohort study".PSYCHOLOGICAL MEDICINE 54..6(2024):1102-1112
医学