Whole-protein enteral nutrition formula supplementation reduces Escherichia and improves intestinal barrier function in HIV-infected immunological nonresponders
机构:[1]School of Medicine, Kunming University, Kunming, China[2]NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University and Research Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院国家卫生健康委毒品依赖和戒治重点实验室国家级重点实验室[3]Department of Gastrointestinal and Hernia Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, China外科科室普通外科普通外一科(胃肠与疝外科)昆明医科大学附属第一医院[4]Yunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan University, Kunming, China[5]Department of Dermatology, Second People's Hospital of Dali City, Dali, China
People living with human immunodeficiency virus (PLWH) have persistent malnutrition, intestinal barrier dysfunction, and gut microbial imbalance. The interplay between gut microbiota and nutrients is involved in the immune reconstitution of PLWH. To evaluate the effects of whole-protein enteral nutrition formula supplementation on T-cell levels, intestinal barrier function, nutritional status, and gut microbiota composition in human immunodeficiency virus (HIV)-infected immunological nonresponders (INRs) who failed to normalize CD4+ T-cell counts, with a number <350 cells/mu L, a pilot study was carried out in 13 HIV-infected INRs undergoing antiretroviral therapy who received a 3-month phase supplementation of 200 mL/200 kcal/45 g whole-protein enteral nutrition formula once daily. Our primary endpoint was increased CD4+ T-cell counts. Secondary outcome parameters were changes in intestinal barrier function, nutritional status, and gut microbiota composition. We showed that CD4+ T-cell counts of HIV-infected INRs increased significantly after the 3-month supplementation. Dietary supplementation for 3 months improved the intestinal barrier function and nutritional status of HIV-infected INRs. Furthermore, the enteral nutrition formula significantly decreased the relative abundance of Escherichia at the genus level and increased the alpha diversity of gut microbiota in HIV-infected INRs. The findings demonstrated that the whole-protein enteral nutrition formula aids in reducing Escherichia and improving intestinal barrier function in HIV-infected INRs. This study provides insight into the role of nutrients in the improvement of immune reconstitution in HIV-infected INRs. This study is registered in the Chinese Clinical Trial Registry (Document No. ChiCTR2000037839; http://www.chictr.org.cn/index.aspx).
基金:
Yunnan Province Postdoctoral Management Committee Office [2019M663580]
第一作者机构:[1]School of Medicine, Kunming University, Kunming, China[2]NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University and Research Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China
共同第一作者:
通讯作者:
通讯机构:[2]NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University and Research Center for Clinical Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China[4]Yunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan University, Kunming, China[*1]NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, 295 Xichang Road, Kunming, China[*2]Yunnan Technological Innovation Centre of Drug Addiction Medicine, Yunnan University, Kunming, China
推荐引用方式(GB/T 7714):
Lu Danfeng,Wang Yue-Xin,Geng Shi-Tao,et al.Whole-protein enteral nutrition formula supplementation reduces Escherichia and improves intestinal barrier function in HIV-infected immunological nonresponders[J].APPLIED PHYSIOLOGY NUTRITION AND METABOLISM.2024,49(3):319-329.doi:10.1139/apnm-2022-0450.
APA:
Lu, Danfeng,Wang, Yue-Xin,Geng, Shi-Tao,Zhang, Zunyue,Xu, Yu...&Kuang, Yi-Qun.(2024).Whole-protein enteral nutrition formula supplementation reduces Escherichia and improves intestinal barrier function in HIV-infected immunological nonresponders.APPLIED PHYSIOLOGY NUTRITION AND METABOLISM,49,(3)
MLA:
Lu, Danfeng,et al."Whole-protein enteral nutrition formula supplementation reduces Escherichia and improves intestinal barrier function in HIV-infected immunological nonresponders".APPLIED PHYSIOLOGY NUTRITION AND METABOLISM 49..3(2024):319-329