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DTL promotes head and neck squamous cell carcinoma progression by mediating the degradation of ARGLU1 to regulate the Notch signaling pathway

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收录情况： ◇ SCIE

作者：
Shi Jingpei[1,2] ; Yu Xiaonan[1] ; Li Guoyu[3] ; Zhao Xiaoyu[4] ; Chen Jiwen[2] ; Fang Ying[5] ; Yang Yan[6] ; Wang Ting[2] ; Xu Tianyong[2] ; Bian Li[7] ; Lyu Lechun[2,*1] ; He Yongwen[1,8,*2] ;
机构： [1]Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650106, Yunnan, China [2]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming 650500, Yunnan, China [3]Department of Colorectal Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, Yunnan, China [4]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032,Yunnan, China [5]Department of Infection and Hepatology, The First Affiliated Hospital of Kunming Medical University, 650032, Yunnan, China [6]Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantion, the First People’s Hospital of Kunming, Kunming 650011, Yunnan, China [7]Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China h Qujing Medical College, Qujing 655099, Yunnan, China
出处：
DOI： 10.1016/j.ijbiomac.2023.129184
ISSN：

关键词： head and neck squamous cell carcinoma DTL ARGLU1 Notch signaling pathway

摘要：
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with a high incidence in squamous epithelium. The E3 ubiquitin ligase DTL is a component of the CRL4A complex and is widely involved in tumor progression. We aimed to analyze the role of DTL in HNSCC and to explore its mechanism of action. Through clinical analysis, we found that DTL is upregulated in HNSCC tissues and is associated with the tumor microenvironment and poor survival in patients. Through gain-of-function and loss-of-function assays, we showed that DTL promotes cell proliferation and migration in vitro and tumor growth in vivo. Mass spectrometry analysis and immunoprecipitation assays showed that DTL interacts with ARGLU1 to promote K11-linked ubiquitination-mediated degradation of ARGLU1, thereby promoting the activation of the CSL-dependent Notch signaling pathway. Furthermore, siARGLU1 blocks the inhibitory effects of DTL knockdown on HNSCC cells. In this study, we showed that DTL promotes HNSCC progression through K11-linked ubiquitination of ARGLU1 to activate the CSL-dependent Notch pathway. These findings identify a promising therapeutic target for HNSCC.Copyright © 2023. Published by Elsevier B.V.

基金：
This study was supported by the National Natural Science Foundation of China (NSFC; Grant Nos. 82060496, 81960354), the National Natural Science Foundation of Yunnan Province (Grant Nos. 202101AY070001-012, 202101AY070001-079), the Talent Project of Yunnan Province (2019HB024), the Foundation of Yunnan Educational Committee (2023Y0789) and the Doctoral Student Innovation Fund (2023B007).
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外文
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最新[2023]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 高分子科学 2 区 生化与分子生物学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650106, Yunnan, China [2]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming 650500, Yunnan, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650106, Yunnan, China [2]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming 650500, Yunnan, China [*1]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Science and Technology Achievement Incubation Center, Kunming Medical University, 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, Yunnan 650500, China. [*2]Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Kunming Medical University, Kunming 650106, China.
推荐引用方式(GB/T 7714)：
Shi Jingpei,Yu Xiaonan,Li Guoyu,et al.DTL promotes head and neck squamous cell carcinoma progression by mediating the degradation of ARGLU1 to regulate the Notch signaling pathway[J].INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024,259:129184.doi:10.1016/j.ijbiomac.2023.129184.
APA：
Shi Jingpei,Yu Xiaonan,Li Guoyu,Zhao Xiaoyu,Chen Jiwen...&He Yongwen.(2024).DTL promotes head and neck squamous cell carcinoma progression by mediating the degradation of ARGLU1 to regulate the Notch signaling pathway.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,259,
MLA：
Shi Jingpei,et al."DTL promotes head and neck squamous cell carcinoma progression by mediating the degradation of ARGLU1 to regulate the Notch signaling pathway".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 259.(2024):129184

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