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Identification of cuproptosis-related molecular classification and characteristic genes in ulcerative colitis

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机构： [1]Kunming Medical University, Kunming, China. [2]Yunnan Province Clinical Research Center for Digestive Diseases, Kunming, China. [3]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

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关键词： Ulcerative colitis Cuproptosis Molecular clusters Machine learning Immune infiltration

摘要：

Ulcerative colitis (UC) is a refractory inflammatory disease with imbalances in intestinal mucosal homeostasis. Cuproptosis serves as newly identified programmed cell death (PCD) form involved in UC. In the study, UC-related datasets were extracted from the Gene Expression Omnibus (GEO) database. A comparison of UC patients and healthy controls identified 11 differentially expressed cuproptosis-related genes (DE-CRGs), where FDX1, LIAS, and DLAT were differentially expressed in UC groups from the mouse models and clinical samples, with their expression correlating with disease severity. By comprehending weighted gene co-expression network analysis (WGCNA) and differential expression analysis, the key genes common to the module genes relevant to different cuproptosis-related clusters and differentially expressed genes (DEGs) both in different clusters and patients with and without UC were identified using several bioinformatic analysis. Furthermore, the mRNA levels of four characteristic genes with diagnostic potential demonstrated significant decrease in both mouse models and clinical UC samples. Our discoveries offer a theoretical foundation for cuproptosis effect in UC.© 2024 The Authors.

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大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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无

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Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.4 最新[2023版] 3.9 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 3.4 出版前一年[2023版]

第一作者：

第一作者机构： [1]Kunming Medical University, Kunming, China. [2]Yunnan Province Clinical Research Center for Digestive Diseases, Kunming, China.

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通讯作者：

通讯机构： [2]Yunnan Province Clinical Research Center for Digestive Diseases, Kunming, China. [3]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.

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