个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：
Bo-Gyeom Kim [1] * ; Gakyung Kim[2] * ; Yoshinari Abe [3] ; Pino Alonso [4,5,6] ; Stephanie Ameis[7,8,9] ; Alan Anticevic[10] ; Paul D. Arnold [11,12] ; Srinivas Balachander[13] ; Nerisa Banaj [14] ; Nuria Bargalló[15,16] ; Marcelo C. Batistuzzo [17,18] ; Francesco Benedetti [19,20] ; Sara Bertolín [5,21] ; Jan Carl Beucke[22,23,24] ; Irene Bollettini [20] ; Silvia Brem[25,26] ; Brian P. Brennan [27,28] ; Jan K. Buitelaar[29,30] ; Rosa Calvo [5,31,32,33] ; Miguel Castelo-Branco[34,35,36] ; Yuqi Cheng[37] ; Ritu Bhusal Chhatkuli[38,39] ; Valentina Ciullo[14] ; Ana Coelho[40,41,42] ; Beatriz Couto[40,41,42] ; Sara Dallaspezia[43] ; Benjamin A. Ely [44] ; Sónia Ferreira[40,41,42] ; Martine Fontaine[45] ; Jean-Paul Fouche[46] ; Rachael Grazioplene [10] ; Patricia Gruner[10] ; Kristen Hagen[47,48] ; Bjarne Hansen[48,49] ; Gregory L. Hanna[50] ; Yoshiyuki Hirano [38,39] ; Marcelo Q. Höxter[17] ; Morgan Hough[51] ; Hao Hu[52] ; Chaim Huyser [53,54] ; Toshikazu Ikuta [55] ; Neda Jahanshad[56] ; Anthony James [57] ; Fern Jaspers-Fayer [58,59] ; Selina Kasprzak[60,61] ; Norbert Kathmann[22] ; Christian Kaufmann[22] ; Minah Kim [62,63] ; Kathrin Koch [64,65] ; Gerd Kvale[48,66] ; Jun Soo Kwon [63,67,68] ; Luisa Lazaro [5,31,32,33] ; Junhee Lee [62,69] ; Christine Lochner[70] ; Jin Lu[71] ; Daniela Rodriguez Manrique[64,65,72] ; Ignacio Martínez-Zalacaín [4,73] ; Yoshitada Masuda[74] ; Koji Matsumoto[74] ; Maria Paula Maziero[75,76] ; Jose M. Menchón [4,5,6] ; Luciano Minuzzi[77,78] ; Pedro Silva Moreira [40,41,79] ; Pedro Morgado[40,41,42] ; Janardhanan C. Narayanaswamy[13] ; Jin Narumoto[80] ; Ana E. Ortiz[31,32,33] ; Junko Ota[38,39] ; Jose C. Pariente [16] ; Chris Perriello[81] ; Maria Picó-Pérez [40,41,82] ; Christopher Pittenger [10,83,84,85] ; Sara Poletti [20] ; Eva Real[5,6] ; Y. C. Janardhan Reddy[13] ; Daan van Rooij[86] ; Yuki Sakai [80,87] ; João Ricardo Sato[88,89] ; Cinto Segalas[5,6] ; Roseli G. Shavitt[90] ; Zonglin Shen[37] ; Eiji Shimizu [38,39,91] ; Venkataram Shivakumar[92] ; Carles Soriano-Mas [5,6,93] ; Nuno Sousa [40,41,42] ; Mafalda Machado Sousa[40,41,42] ; Gianfranco Spalletta[14,94] ; Emily R. Stern[95,96] ; S. Evelyn Stewart [58,97,98] ; Philip R. Szeszko[99,100] ; Rajat Thomas[101] ; Sophia I. Thomopoulos[56] ; Daniela Vecchio[14] ; Ganesan Venkatasubramanian[13] ; Chris Vriend[60,61,102] ; Susanne Walitza[25,26] ; Zhen Wang [103] ; Anri Watanabe [80] ; Lidewij Wolters[104] ; Jian Xu[105] ; Kei Yamada[106] ; Je-Yeon Yun [107,108] ; Mojtaba Zarei[109] ; Qing Zhao[103] ; Xi Zhu[110,111] ; Paul M. Thompson[56] ; Willem B. Bruin[102,112] ; Guido A. van Wingen [102,112] ; Federica Piras[14] ; Fabrizio Piras [14] ; Dan J. Stein [113,114] ; Odile A. van den Heuvel [60,61] ; Helen Blair Simpson[45] ; Rachel Marsh [45] ; Jiook Cha [1,2] ;
机构： [1]Department of Psychology, College of Social Sciences, Seoul National University, Seoul, Republic of Korea. [2]Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea. [3]Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Department of Psychiatry, Kyoto City, Japan. [4]Bellvitge Biomedical Research Insitute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain. [5]CIBER of Mental Health (CIBERSAM), Carlos III Health Institute, Madrid, Spain. [6]Department of Clinical Sciences, University of Barcelona, Barcelona, Spain. [7]The Margaret and Wallace McCain Centre for Child, Youth & Family Mental Health and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. [8]Department of Psychiatry, University of Toronto, Toronto, ON, Canada. [9]Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada. [10]Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA. [11]The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. [12]Departments of Psychiatry and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. [13]OCD clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India. [14]Laboratory of Neuropsychiatry, Department of Clinical and Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy. [15]Center of Image Diagnostic, Hospital Clínic de Barcelona, Barcelona, Spain. [16]Magnetic Resonance Image Core Facility, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [17]Departamento e Instituto de Psiquiatria do Hospital das Clinicas, IPQ HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. [18]Department of Methods and Techniques in Psychology, Pontifical Catholic University, São Paulo, SP, Brazil. [19]Vita-Salute San Raffaele University, Milano, Italy. [20]Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy. [21]Bellvitge Biomedical Research Institute-IDIBELL, Bellvitge University Hospital, Barcelona, Spain. [22]Department of Psychology, Humboldt-Universitat zu Berlin, Berlin, Germany. [23]Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden. [24]Department of Medical Psychology, Medical School Hamburg, Hamburg, Germany. [25]Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland. [26]Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland. [27]McLean Hospital, Belmont, MA, USA. [28]Department of Psychiatry, Harvard Medical School, Boston, MA, USA. [29]Radboudumc, Department of Cognitive Neuroscience, Nijmegen, The Netherlands. [30]Karakter Child and Adolescent Psychiatry University Center, Nijmegen, The Netherlands. [31]Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain. [32]Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [33]Department of Medicine, University of Barcelona, Barcelona, Spain. [34]Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, 3000-548 Coimbra, Portugal. [35]Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, 3000-548 Coimbra, Portugal. [36]Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. [37]Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China. [38]Research Center for Child Mental Development, Chiba University, Chiba, Japan. [39]United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University, Chiba University and University of Fukui, Suita, Japan. [40]Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. [41]ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimaraes, Portugal. [42]Clinical Academic Center - Braga, Braga, Portugal. [43]Psychiatry & Clinical Psychobiology Unit, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milano, Italy. [44]Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA. [45]Columbia University Medical College, Columbia University, New York, NY, USA. [46]SAMRC Genomics of Brain Disorders Unit, Department of Psychiatry, Cape Town, South Africa. [47]Hospital of Molde, Møre og Romsdal Hospital Trust, Molde, Norway. [48]Bergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway. [49]Centre for Crisis Psychology, University of Bergen, Bergen, Norway. [50]Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA. [51]Highfield Unit Oxford, Warneford Hospital, Warneford Lane, Headington, Oxford, Oxfordshire OX3 7JX, UK. [52]Shanghai Mental Health Center, Shanghai, China. [53]Levvel, academic center for child and adolescent care, Amsterdam, The Netherlands. [54]Department of Child and Adolescent Psychiatry, Amsterdam UMC, Amsterdam, The Netherlands. [55]Department of Communication Sciences and Disorders, University of Mississippi, Oxford, MS, USA. [56]Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, Los Angeles, CA, USA. [57]Department of Psychiatry University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK. [58]Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. [59]BC Children’s Hospital Research Institute, Vancouver, BC, Canada. [60]Amsterdam UMC, Vrije Universteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands. [61]Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam, The Netherlands. [62]Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. [63]Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. [64]TUMNeuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universitat Munchen, München, Germany. [65]Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany. [66]Department of Clinical Psychology, University of Bergen, Bergen, Norway. [67]Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea. [68]Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. [69]Department of Psychiatry, Uijeongbu Eulji Medical Center, Uijeongbu, Republic of Korea. [70]SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa. [71]Department of Psychiatry, First Affiliated Hospitalof Kunming Medical University, Kunming, China. [72]Graduate School of Systemic Neurosciences, Ludwig-Maximilians-University, Munich, Germany. [73]Department of Radiology, Bellvitge University Hospital, Barcelona, Spain. [74]Chiba University Hospital, Chiba University, Chiba, Japan. [75]LIM 23, Instituto de Psiquiatria, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. [76]Faculty of Medicine, City University of Sao Paulo, Sao Paulo, Brazil. [77]Anxiety Treatment and Research Clinic, St. Joseph’s Hamilton Healthcare, Hamilton, ON, Canada. [78]Dapartmente of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. [79]Psychological Neuroscience Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal. [80]Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. [81]University of Illinois at Urbana-Champaign, Champaign, IL, USA. [82]Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castelló de la Plana, Spain. [83]Department of Psychology, Yale University, New Haven, CT, USA. [84]Child Study Center, Yale University, New Haven, CT, USA. [85]Center for Brain and Mind Health, Yale University, New Haven, CT, USA. [86]Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, Nijmegen, The Netherlands. [87]ATR Brain Information Communication Research Laboratory Group, Kyoto, Japan. [88]Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, Santo André, Brazil. [89]Big Data, Hospital Israelita Albert Einstein, São Paulo, Brazil. [90]Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. [91]Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan. [92]National Institute of Mental Health and Neurosciences, Department of Integrative Medicine, Bengaluru, India. [93]Department of Social Psychology and Quantitative Psychology, University of Barcelona, Barcelona, Spain. [94]Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Science, Baylor College of Medicine, Houston, TX, USA. [95]Department of Psychiatry, New York University School of Medicine, New York, NY, USA. [96]Clinical Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA. [97]British Columbia Children’s Hospital, Psychiatry, Vancouver, BC, Canada. [98]British Columbia Mental Health and Substance Use Services Research Institute, Vancouver, BC, Canada. [99]Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [100]Mental Illness Research, Education and Clinical Center, James J. Peters VA Medical Center, Bronx, NY, USA. [101]Weill-Cornell Medicine Qatar, Education City, Doha, Qatar. [102]Amsterdam Neuroscience, Compulsivity, Impulsivity & Attention program, Amsterdam, The Netherlands. [103]Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [104]Norwegian University of Science and Technology (NTNU), Faculty of Medicine, Regional Centre for Child and Youth Mental Health and Child Welfare (RKBU Central Norway), Klostergata 46, 7030 Trondheim, Norway. [105]Department of Internal Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China. [106]Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. [107]Seoul National University Hospital, Seoul, Republic of Korea. [108]Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea. [109]Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran. [110]Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA. [111]New York State Psychiatric Institute, New York, NY, USA. [112]Amsterdam UMC, Universiteit van Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands. [113]Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. [114]SAMRC Unit on Risk & Resilience in Mental Disorders, Cape Town, South Africa.
出处：
DOI： 10.1038/s41380-023-02392-6
ISSN：

摘要：
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group. We used an automatic machine learning pipeline (with feature engineering and selection, and model optimization) and examined the cross-site generalizability of the OCD classification models using leave-one-site-out cross-validation. Our models showed low-to-moderate accuracy in classifying (1) "OCD vs. healthy controls" (Adults, receiver operator characteristic-area under the curve = 57.19 ± 3.47 in the replication set; Children, 59.8 ± 7.39), (2) "unmedicated OCD vs. healthy controls" (Adults, 62.67 ± 3.84; Children, 48.51 ± 10.14), and (3) "medicated OCD vs. unmedicated OCD" (Adults, 76.72 ± 3.97; Children, 72.45 ± 8.87). There was significant site variability in model performance (cross-validated ROC AUC ranges 51.6-79.1 in adults; 35.9-63.2 in children). Machine learning interpretation showed that diffusivity measures of the corpus callosum, internal capsule, and posterior thalamic radiation contributed to the classification of OCD from HC. The classification performance appeared greater than the model trained on grey matter morphometry in the prior ENIGMA OCD study (our study includes subsamples from the morphometry study). Taken together, this study points to the meaningful multivariate patterns of white matter features relevant to the neurobiology of OCD, but with low-to-moderate classification accuracy. The OCD classification performance may be constrained by site variability and medication effects on the white matter integrity, indicating room for improvement for future research.© 2024. The Author(s).

基金：
New Faculty Startup Fund from Seoul National University by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 1711131839)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 神经科学 1 区 精神病学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 NEUROSCIENCES Q1 PSYCHIATRY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Psychology, College of Social Sciences, Seoul National University, Seoul, Republic of Korea.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Psychology, College of Social Sciences, Seoul National University, Seoul, Republic of Korea. [2]Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
推荐引用方式(GB/T 7714)：
Bo-Gyeom Kim,Gakyung Kim,Yoshinari Abe,et al.White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group[J].Molecular Psychiatry.2024,doi:10.1038/s41380-023-02392-6.
APA：
Bo-Gyeom Kim,Gakyung Kim,Yoshinari Abe,Pino Alonso,Stephanie Ameis...&Jiook Cha.(2024).White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group.Molecular Psychiatry,,
MLA：
Bo-Gyeom Kim,et al."White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group".Molecular Psychiatry .(2024)

资源点击量：56774 今日访问量：1 总访问量：1770 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 昆明医科大学第一附属医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西昌路295号(650032)