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Subcortical neural mechanisms of childhood trauma impacts on personality traits

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chu Zhaosong[1,2] ; Wang Xin[1,2] ; Cheng Yuqi[1,2] ; Yuan Lijin[1,2] ; Jin Mengyun[1,2] ; Lu Yi[3] ; Shen Zonglin[1] ; Xu Xiufeng[2] ;
机构： [1]Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [2]Yunnan Province Clinical Research Center for Mental Health, Kunming 650032, China [3]Department of Medical Imaging, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
出处：
DOI： 10.1016/j.ajp.2024.103966
ISSN：

关键词： Childhood trauma Hippocampus Personality Neuroticism Subcortical Structural MRI

摘要：
This study aims to explore the relationships between childhood trauma (CT), personality traits, and subcortical structures. 171 healthy individuals completed the Childhood Trauma Questionnaire (CTQ), the Neuroticism-Extraversion-Openness Five-Factor Inventory (NEO-FFI), and underwent 3D T1-weighted MRI scans. Linear regression analyses indicated the complex relationship between CT, personality traits, and subcortical gray matter volume (GMV). Mediation analyses revealed that the right hippocampal GMV partially mediated the effects of CT on neuroticism. These findings suggest that CT affects the development of the Big Five personality traits, and alterations in subcortical structures are closely related to this process. Altered GMV in the right hippocampus may be a key neural mechanism for CT-induced neuroticism.Copyright © 2024. Published by Elsevier B.V.

基金：
National Natural Science Foundation of China (81660237, 82260277, 82060259), the Yunnan Clinical Research Center for Mental Disorders (202102AA100058), the Yunnan Fundamental Research Projects (202301AT070126), the Yunnan Health Training Project of High-Level Talents (H-2018090), and the Yunnan Basic Research Projects Union Foundation [2019FE001(− 144)].
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 精神病学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 PSYCHIATRY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [2]Yunnan Province Clinical Research Center for Mental Health, Kunming 650032, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Chu Zhaosong,Wang Xin,Cheng Yuqi,et al.Subcortical neural mechanisms of childhood trauma impacts on personality traits[J].Asian Journal Of Psychiatry.2024,94:103966.doi:10.1016/j.ajp.2024.103966.
APA：
Chu Zhaosong,Wang Xin,Cheng Yuqi,Yuan Lijin,Jin Mengyun...&Xu Xiufeng.(2024).Subcortical neural mechanisms of childhood trauma impacts on personality traits.Asian Journal Of Psychiatry,94,
MLA：
Chu Zhaosong,et al."Subcortical neural mechanisms of childhood trauma impacts on personality traits".Asian Journal Of Psychiatry 94.(2024):103966

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