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The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Bi Shijia[1,3,5] * ; Jiang Xiaoyu[2,3,5] * ; Ji Qianzhao[2,3,5] * ; Wang Zehua[1,3,5] * ; Ren Jie[4,,5,6,16] * ; Wang Si[8,9,17] * ; Yu Yang[10] * ; Wang Ruoqi[5,15] ; Liu Zunpeng[1,3,5] ; Liu Junhang[2,3,5] ; Hu Jianli[4,5] ; Sun Guoqiang[2,3,5] ; Wu Zeming[2,3,6,7] ; Diao Zhiqing[1,3,5] ; Li Jingyi[2,3,5,6,7] ; Sun Liang[11,12] ; Izpisua Belmonte Juan Carlos[14,18] ; Zhang Weiqi[4,5,6,13] ; Liu Guang-Hui[2,3,5,6,7,8,9,13] ; Qu Jing[1,3,5,6,7,13] ;
机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [5]University of Chinese Academy of Sciences, Beijing 100049, China [6]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [8]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [9]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [10]Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China [11]NHC Beijing Institute of Geriatrics, NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine of Chinese Academy of Medical Sciences, National Center of Gerontology/Beijing Hospital, Beijing 100730, China [12]Department of Clinical Laboratory,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China [13]Aging Biomarker Consortium, Beijing 100101, China [14]Altos Labs, San Diego, CA 92121, USA [15]National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [16]Key Laboratory of RNA Science and Engineering, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [17]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China
出处：
DOI： 10.1016/j.devcel.2024.02.008
ISSN：

摘要：
Sirtuins are pro-longevity genes with chromatin modulation potential, but how these properties are connected is not well understood. Here, we generated a panel of isogeneic human stem cell lines with SIRT1-SIRT7 knockouts and found that any sirtuin deficiency leads to accelerated cellular senescence. Through large-scale epigenomic analyses, we show how sirtuin deficiency alters genome organization and that genomic regions sensitive to sirtuin deficiency are preferentially enriched in active enhancers, thereby promoting interactions within topologically associated domains and the formation of de novo enhancer-promoter loops. In all sirtuin-deficient human stem cell lines, we found that chromatin contacts are rewired to promote aberrant activation of the placenta-specific gene PAPPA, which controls the pro-senescence effects associated with sirtuin deficiency and serves as a potential aging biomarker. Based on our survey of the 3D chromatin architecture, we established connections between sirtuins and potential target genes, thereby informing the development of strategies for aging interventions.Copyright © 2024 Elsevier Inc. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China (82125011, 81921006, 92149301, 82122024, 92049304, 92168201, and 32121001), the National Key Research and Development Program of China (2020YFA0804000, 2022YFA1103700, 2020YFA0112200, 2021YFF1201005, the STI2030-Major Projects-2021ZD0202400, 2022YFA1103800, 2020YFA 0113400, 2019YFA0802202, and 2020YFA0803401), the National Natural Science Foundation of China (91949209, 92049116, 82192863, 82071588, 32100937, and 31970597), CAS Project for Young Scientists in Basic Research (YSBR-076, YSBR-012, and YSBR-036), the Program of the Beijing Natural Science Foundation (Z230011), New Cornerstone Science Foundation through the XPLORER PRIZE (2021-1045), Youth Innovation Promotion Association of CAS (E1CAZW0401, 2020085), the Informatization Plan of Chinese Academy of Sciences (CAS-WX2022SDC-XK14), Excellent Young Talents Program of Capital Medical University (12300927), The Project for Technology Development of Beijing-affiliated Medical Research Institutes (11000023 T000002036310), Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team (BPHR202203105), CAS Special Research Assistant (SRA) Program, and Young Elite Scientists Sponsorship Program by CAST (2023QNRC001).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学 1 区 发育生物学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 CELL BIOLOGY Q1 DEVELOPMENTAL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [5]University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China [5]University of Chinese Academy of Sciences, Beijing 100049, China [6]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [8]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [9]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [13]Aging Biomarker Consortium, Beijing 100101, China
推荐引用方式(GB/T 7714)：
Bi Shijia,Jiang Xiaoyu,Ji Qianzhao,et al.The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA[J].Developmental Cell.2024,59(8):doi:10.1016/j.devcel.2024.02.008.
APA：
Bi Shijia,Jiang Xiaoyu,Ji Qianzhao,Wang Zehua,Ren Jie...&Qu Jing.(2024).The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA.Developmental Cell,59,(8)
MLA：
Bi Shijia,et al."The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA".Developmental Cell 59..8(2024)

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