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Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys

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收录情况： ◇ SCIE

作者：
Xu Jianglei[1,2,3] * ; Li Hao[1,2] * ; Hu Yingzhou[1,2] * ; Wu Shihao[4] * ; Wu Liping[5] * ; Lei Xiaoguang[6] * ; Lv Longbao[1,2,3] ; Lu Yi[7] ; Wu Jing[1,2] ; Li Juanjuan[8] ; Shi Bingyin[5] ; Li Jiali[9] ; Turck Christoph W[1,2,10] ; Wang Wenchao[1,2] ; Hu Xintian[1,2] ;
机构： [1]National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Genetic Evolution & Animal Models, and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China [2]Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China [3]Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming 650204, China [4]School of Medicine, Yunnan University, Kunming, Yunnan 650000, China [5]Department of Endocrinology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China [6]First Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China [7]Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming 650000, China [8]Department of Ophthalmology, Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650051, China [9]Department of Neurology, Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA [10]Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, 80804 Munich, Germany
出处：
DOI： 10.1016/j.isci.2024.109436
ISSN：

摘要：
Cerebrospinal fluid (CSF) samples are commonly collected via lumbar puncture (LP) in both clinical and research settings for measurement of biomarkers of Alzheimer's disease (AD). To determine the effects of LP on CSF AD biomarkers, we collected CSF samples at seven different time points after an LP in rhesus monkeys. We find that amyloid-beta (Aβ) and Tau levels increased significantly on day 1, peaked on day 3, and returned to baseline on day 10 after LP. The NFL levels increased significantly on day 5, peaked on day 10, and returned to baseline after day 30. The increased AD biomarker levels were mainly due to CSF outflow and deep intrathecal invasion during LP. Therefore, if LPs are repeated within a short period of time, prior LP can affect Aβ and Tau levels within 10 days and NFL levels within 30 days, which may lead to clinical misdiagnosis or incorrect scientific conclusions.© 2024 The Authors.

基金：
This work was supported by the National Key Research and Development Program of China (2021YFF0702700), STI2030-Major Projects (2021ZD0200900), Key Area Research and Development Program of Guangdong Province (2019B030335001), National Key Research and Development Program of China (2018YFA0801403), National Natural Science Foundation of China (81960422, 32100801, 82101241, 82360226), Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) (XDB32060200), STI2030-Major Projects (2022ZD0205200, 2022ZD0212700), Yunnan Province (202305AH340006, 202305AH340007), Yunnan Fundamental Research Projects (202201AT070153, 202201AT070139), Science and Technology Project of Yunnan Province (202101AY070001-001), Yunnan Revitalization Talent Support Program (YNWR-QNBJ-2019-043), CAS ‘‘Light of West China’’ Program, and ‘‘Yunnan Revitalization Talents Support Plan’’.
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大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
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Q1 MULTIDISCIPLINARY SCIENCES

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第一作者：
第一作者机构： [1]National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Genetic Evolution & Animal Models, and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China [2]Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China [3]Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming 650204, China
共同第一作者：
通讯作者：
通讯机构： [1]National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Genetic Evolution & Animal Models, and National Resource Center for Non-Human Primates, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China [2]Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China [10]Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, 80804 Munich, Germany
推荐引用方式(GB/T 7714)：
Xu Jianglei,Li Hao,Hu Yingzhou,et al.Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys[J].ISCIENCE.2024,27(4):109436.doi:10.1016/j.isci.2024.109436.
APA：
Xu Jianglei,Li Hao,Hu Yingzhou,Wu Shihao,Wu Liping...&Hu Xintian.(2024).Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys.ISCIENCE,27,(4)
MLA：
Xu Jianglei,et al."Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys".ISCIENCE 27..4(2024):109436

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