机构：[1]Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China[2]NHC Key Laboratory of Myopia, Fudan University, Shanghai, China[3]Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China[4]Ruoyan Wei is also affiliated to Shanghai Medical College and Zhongshan Hospital Immunotherapy Translational Research Center, Shanghai, China[5]Department of Ophthalmology, Affiliated Hospital of Yunnan University, Kunming, China[6]Department of Ophthalmology, Children’s Hospital of Fudan University, Shanghai, China[7]Beijing Airdoc Technology Co., Ltd, Beijing, China[8]Monash University, Clayton, Victoria, Australia[9]Department of Biostatistics, School of Public Health, and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China[10]First Affiliated Hospital of Kunming Medical University, Kunming, China昆明医科大学附属第一医院[11]Kunming Medical University, Kunming, China[12]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Purpose: To investigate fundus tessellation density (TD) and its association with axial length (AL) elongation and spherical equivalent (SE) progression in children. Methods: The school-based prospective cohort study enrolled 1,997 individuals aged 7 to 9 years in 11 elementary schools in Mojiang, China. Cycloplegic refraction and biometry were performed at baseline and 4-year visits. The baseline fundus photographs were taken, and TD, defined as the percentage of exposed choroidal vessel area in the photographs, was quantified using an artificial intelligence-assisted semiautomatic labeling approach. After the exclusion of 330 ineligible participants because of loss to follow-up or ineligible fundus photographs, logistic models were used to assess the association of TD with rapid AL elongation (>0.36 mm/year) and SE progression (>1.00 D/year). Results: The prevalence of tessellation was 477 of 1,667 (28.6%) and mean TD was 0.008 +/- 0.019. The mean AL elongation and SE progression in 4 years were 0.90 +/- 0.58 mm and -1.09 +/- 1.25 D. Higher TD was associated with longer baseline AL (beta, 0.030; 95% confidence interval: 0.015-0.046; P < 0.001) and more myopic baseline SE (beta, -0.017; 95% confidence interval: -0.032 to -0.002; P = 0.029). Higher TD was associated with rapid AL elongation (odds ratio, 1.128; 95% confidence interval: 1.055-1.207; P < 0.001) and SE progression (odds ratio, 1.123; 95% confidence interval: 1.020-1.237; P = 0.018). Conclusion: Tessellation density is a potential indicator of rapid AL elongation and refractive progression in children. TD measurement could be a routine to monitor AL elongation.
基金：
Shanghai Yangfan Project (23YF1445300),National Natural Science Foundation of China (82301251,82371091), Yunnan Province young and middle-aged academic
and technical leaders reserve Talents Project (No. 2019HB051),
Basic Research Program of Yunnan Province (No. 2019FE001(-
096)), Yunnan Province “High-level Talent Training Support Program” special famous doctors (YNWR-MY-2020-094), Construction of a 3D digital intelligent prevention and control platform for
the whole life cycle of highly myopic patients in the Yangtze River
Delta (21002411600), Project of Shanghai Xuhui District Science
and Technology (2020-015, XHLHGG202104), Shanghai RisingStar Program (21QA1401500), and Natural Science Foundation of Shanghai (23ZR1409200).
第一作者机构：[1]Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China[2]NHC Key Laboratory of Myopia, Fudan University, Shanghai, China[3]Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China[4]Ruoyan Wei is also affiliated to Shanghai Medical College and Zhongshan Hospital Immunotherapy Translational Research Center, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ophthalmology and Optometry, Eye and ENT Hospital, Fudan University, Shanghai, China[2]NHC Key Laboratory of Myopia, Fudan University, Shanghai, China[3]Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China
推荐引用方式(GB/T 7714)：
Wei Ruoyan,Li Jun,Yang Weiming,et al.ASSOCIATION OF TESSELLATION DENSITY WITH PROGRESSION OF AXIAL LENGTH AND REFRACTION IN CHILDREN An Artificial Intelligence-Assisted 4-Year Study[J].RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES.2024,44(3):527-536.doi:10.1097/IAE.0000000000003991.
APA：
Wei, Ruoyan,Li, Jun,Yang, Weiming,Liu, Chang,Wang, Yunzhe...&Li, Meiyan.(2024).ASSOCIATION OF TESSELLATION DENSITY WITH PROGRESSION OF AXIAL LENGTH AND REFRACTION IN CHILDREN An Artificial Intelligence-Assisted 4-Year Study.RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,44,(3)
MLA：
Wei, Ruoyan,et al."ASSOCIATION OF TESSELLATION DENSITY WITH PROGRESSION OF AXIAL LENGTH AND REFRACTION IN CHILDREN An Artificial Intelligence-Assisted 4-Year Study".RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 44..3(2024):527-536
