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The microenvironmental factors induced invasive tumor cells in glioblastoma

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机构： [1]Second Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China. [2]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.

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关键词： Single cell RNA-seq Intratumoral heterogeneity Tumor microenvironment Tumor invasion

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Glioblastoma (GBM) cells have the potential to switch from being "proliferative cells" to peritumoral "invasive cells". Peritumoral GBM cells have highly invasive properties that allow them to survive surgery, leading to recurrence. The mechanisms underlying the manner in which the tumor microenvironment (TME) regulates the invasiveness of GBM remain unclear. Single-cell RNA sequencing analysis revealed heterogeneity in GBM cells, microglia and macrophages. In this study, the Oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) expression indicated higher invasiveness in core GBM cells. Under environmental stress, the expression of OSMR and LIFR were up-regulated with the effect of hypoxic, acidic, and low-glucose conditions in vitro. Functional experiments revealed that TME stress significantly influences the proliferation, migration and invasion of GBM cells. The differences in core/peripheral TMEs in GBM affected the invasive properties, indicating the significant role of OSMR expression within the TME in tumor progression and postoperative therapy.© 2024 The Authors.

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大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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第一作者机构： [1]Second Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China.

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