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Comparison of Ultrasound-Guided Single-Injection Erector Spinae Plane Block, Retrolaminar Block and Paravertebral Block for Postoperative Analgesia in Single-Incision Video-Assisted Thoracoscopic Surgery: A Three-Arm, Double-Blind, Randomized Controlled Non-Inferiority Trial

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机构： [1]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

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关键词： Erector spinae plane block retrolaminar block paravertebral block anesthesia non-inferiority trial

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Effective postoperative analgesia is critical for thoracic surgery. This study compares the analgesic efficacy of the erector spinae plane block (ESPB), retrolaminar block (RLB), and paravertebral block (TPVB) in single-incision video-assisted thoracoscopic surgery (SITS).Seventy-six patients underwent general anesthesia followed by ultrasound-guided nerve blocks with 20 mL of 0.5% ropivacaine. Primary outcomes included the area under the curve (AUC) of Numeric Rating Scale (NRS) scores during rest and coughing over 24 hours. Secondary outcomes included perioperative opioid use, plasma biomarkers, and postoperative recovery measures.The AUC for NRS was 107.8±10.53 in the ESPB group, 104.8±8.05 in the RLB group, and 103.6±10.42 in the TPVB group, demonstrating non-inferiority for ESPB (difference: 4.2±3.0, 95% CI -1.82 to 10.22) and RLB (difference: 1.2±2.6, 95% CI -3.97 to 6.37) compared to TPVB. No significant differences were observed in opioid use, plasma biomarkers, QoR-15 scores, or adverse events.ESPB and RLB provide non-inferior analgesia compared to TPVB in SITS patients and are effective alternatives that enhance safety.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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大类 | 3 区医学

小类 | 3 区麻醉学 3 区临床神经病学

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第一作者机构： [1]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

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通讯机构： [1]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. [*1]Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming 650500, Yunnan, China

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