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Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer

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收录情况： ◇ SCIE

作者：
Tang Yu[1] * ; Liu Rui[1] * ; Zhu Jing[2] * ; He Qian[2] * ; Pan Chenglong[3] * ; Zhou Zhongmei[4] ; Sun Jian[1] ; Li Fubing[2] ; Zhang Longlong[2] ; Shi Yujie[5] ; Yao Jing[6,7] ; Jiang Dewei[8] ; Chen Ceshi[1,2] ;
机构： [1]Yunnan Key Laboratory of Breast Cancer Precision Medicine, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, 650118, China. [2]Yunnan Key Laboratory of Breast Cancer Precision Medicine, Academy of Biomedical Engineering, Kunming Medical University, Kunming, 650000, China. [3]Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. [4]School of Continuing Education, Kunming Medical University, Kunming, 650021, China. [5]Department of Pathology, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, 450003, China. [6]Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [7]Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [8]Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China.
出处：
DOI： 10.1002/advs.202412096

关键词： basal like breast cancer cell cycle KLF5 RB1 XPO1

摘要：
Basal-like breast cancer (BLBC), overlapping with the subgroup of estrogen receptor (ER), progesterone receptor (PR), and HER2 triple-negative breast cancer, has the worst prognosis and limited therapeutics. The XPO1 gene encodes nuclear export protein 1, a promising anticancer target which mediates nucleus-cytoplasm transport of nuclear export signal containing proteins such as tumor suppressor RB1 and some RNAs. Despite drugs targeting XPO1 are used in clinical, the regulation of XPO1 expression and functional mechanism is poorly understood, especially in BLBC. This study finds that KLF5 is a transcription factor of XPO1, which increases RB1 nuclear export and cell proliferation in BLBC cells. Furthermore, XPO1 interacts with the RNA-binding protein PTBP1 to export FOXO1 mRNA to cytoplasm and thus activates the FOXO1-KLF5 axis as a feedback. This work demonstrates that XPO1 inhibitor KPT-330 in combination with CDK4/6 inhibitor additively suppressed BLBC tumor growth in vivo. These results reveal a novel positive feedback regulation loop between KLF5 and XPO1 and provide a novel treatment strategy for BLBC.© 2025 The Author(s). Advanced Science published by Wiley‐VCH GmbH.

基金：
This work was supported by Noncommunicable Chronic Diseases- National Science and Technology Major Project (2023ZD0502200), National Key R&D Program of China (2020YFA0112300), National Science Foundation of China (U2102203 and 82430084 to C. C.; 82173014 to D.J.). Biomedical Projects of Yunnan Key Science and Technology Program (202302AA310046) and Yunnan Revitalization Talent Support Program (Yunling Scholar to C. C.; Young Scholar to D.J.). Yunnan Provincial Education Department Natural Science Foundation (2023Y0787). Major projects for fundamental research of Yunnan province (202201BC070002), the Innovative Research Team of Yunnan Province [202405AS350016].
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外文
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出版当年[2026]版：
无
最新[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 化学：综合 1 区 材料科学：综合 1 区 纳米科技
JCR分区：
出版当年[2025]版：
无
最新[2024]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2025版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Yunnan Key Laboratory of Breast Cancer Precision Medicine, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, 650118, China.
共同第一作者：
通讯作者：
通讯机构： [1]Yunnan Key Laboratory of Breast Cancer Precision Medicine, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, 650118, China. [2]Yunnan Key Laboratory of Breast Cancer Precision Medicine, Academy of Biomedical Engineering, Kunming Medical University, Kunming, 650000, China. [6]Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [7]Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
推荐引用方式(GB/T 7714)：
Tang Yu,Liu Rui,Zhu Jing,et al.Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer[J].Advanced Science (Weinheim, Baden-Wurttemberg, Germany).2025,12(16):e2412096.doi:10.1002/advs.202412096.
APA：
Tang Yu,Liu Rui,Zhu Jing,He Qian,Pan Chenglong...&Chen Ceshi.(2025).Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer.Advanced Science (Weinheim, Baden-Wurttemberg, Germany),12,(16)
MLA：
Tang Yu,et al."Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer".Advanced Science (Weinheim, Baden-Wurttemberg, Germany) 12..16(2025):e2412096

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