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EFFICACY AND SAFETY OF XELIGEKIMAB IN RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM A PHASE 3 TRIAL

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Zhang, S.[1] * ; Xu, D.[1] ; Wang, X.[2] ; Shujie, L.[3] ; Liu, S.[4] ; Yuan, F.[5] ; Gou, W.[6] ; Xu, B.[7] ; Sun, L.[8,30] ; Gu, J.[9] ; Zhou, D.[10] ; Li, X.[11] ; Kong, N.[12] ; Zhao, Y.[13] ; Hao, J.[14] ; Li, T.[15] ; Fan, X.[16] ; Shu, Q.[17] ; Wei, H.[18] ; Jiang, T.[19] ; Yang, J.[20] ; Qian, L.[21] ; Sun, H.[22] ; Cai, X.[23] ; Jiang, Z.[24] ; Yuan, G.[25] ; Qin, L.[26] ; Yang, M.[27] ; Xu, J.[28,35] ; Fan, W.[29] ; Sun, L.[8,30] ; Zhang, H.[31] ; Zhang, C.[32] ; Zhang, N.[33] ; Da, Z.[34] ; Hu, J.[35] ; Zhang, Z.[24,36] ; Jin, J.[37] ; Liu, J.[38] ; Dai, L.[39] ; Dong, L.[40] ; Wang, W.[41] ; Zeng, X.[1] ;
机构： [1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Minist Sci & Technol, Natl Clin Res Ctr Dermatol & Immunol Dis NCRC DID, Beijing, Peoples R China [2]Shanxi Med Univ, Hosp 2, Taiyuan, Peoples R China [3]Jining 1 Peoples Hosp, Jining, Peoples R China [4]Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China [5]Wuxi Peoples Hosp, Wuxi, Peoples R China [6]Hebei Petro China Cent Hosp, Langfang, Peoples R China [7]Jieyang Peoples Hosp, Jieyang, Peoples R China [8]Nanjing Drum Tower Hosp, Nanjing, Peoples R China [9]Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou, Peoples R China [10]Xuzhou Med Univ, Affiliated Hosp, Xuzhou, Peoples R China [11]Anhui Prov Hosp, Hefei, Peoples R China [12]Fudan Univ, Huashan Hosp, Shanghai, Peoples R China [13]Sichuan Univ, West China Hosp, Chengdu, Peoples R China [14]Cangzhou Peoples Hosp, Cangzhou, Peoples R China [15]Guangdong Second Prov Gen Hosp, Guangzhou, Peoples R China [16]Bengbu Med Univ, Affiliated Hosp 1, Bengbu, Anhui, Peoples R China [17]Shandong Univ, Qilu Hosp, Jinan, Peoples R China [18]North Jiangsu People's Hosp, Yangzhou, Jiangsu, Peoples R China [19]Jilin Prov Peoples Hosp, Changchun, Jilin, Peoples R China [20]Mianyang Cent Hosp, Mianyang, Peoples R China [21]Anhui Med Univ, Affiliated Hosp 2, Hefei, Peoples R China [22]Shandong First Med Univ, Affiliated Prov Hosp, Jinan, Peoples R China [23]Guangzhou First Peoples Hosp, Guangzhou, Peoples R China [24]First Hosp Jilin Univ, Changchun, Jilin, Peoples R China [25]North Sichuan Med Coll, Affiliated Hosp, Nanchong, Peoples R China [26]Huzhou Third Municipal Hosp, Huzhou, Peoples R China [27]Southern Med Univ, Nanfang Hosp, Guangzhou, Peoples R China [28]Kunming Med Univ, Affiliated Hosp 1, Kunming, Peoples R China [29]Xinxiang Cent Hosp, Xinxiang 453000, Henan, Peoples R China [30]Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China [31]Zaozhuang Municipal Hosp, Jining Med Coll, Affiliated Hosp, Zaozhuang, Peoples R China [32]Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai, Peoples R China [33]China Med Univ, Shengjing Hosp, Shenyang, Peoples R China [34]Nantong Univ, Affiliated Hosp, Nantong, Peoples R China [35]Pingxiang Peoples Hosp, Pingxiang, Peoples R China [36]Harbin Univ Technol, Affiliated Hosp 1, Harbin, Peoples R China [37]Yanbian Univ Hosp, Yanbian Hosp, Yanji 133000, Peoples R China [38]Jiujiang First Peoples Hosp, Jiujiang, Jiangxi, Peoples R China [39]Sun Yat Sen Univ, Sun Yat sen Mem Hosp, Guangzhou, Peoples R China [40]HUST, Tongji Med Coll, Wuhan, Peoples R China [41]Chongqing Genrix Biopharmaceut Co Ltd, Chongqing, Peoples R China
出处：
DOI： 10.1136/annrheumdis-2025-eular.B967
ISSN：

关键词： Randomised controlled trial biological DMARD

摘要：
Background: Radiographic axial spondyloarthritis (r-axSpA), also known as ankylosing spondylitis (AS), is a chronic inflammatory autoimmune disease. Interleukin-17A (IL-17A), a cytokine, plays a key role in the pathogenesis of AS. Xeligekimab (GR1501), a fully human monoclonal antibody that selectively neutralizes IL-17A, has demonstrated potential efficacy in treating r-axSpA. This study represents the first phase 3 clinical trial evaluating Xeligekimab as a treatment for r-axSpA.

语种：
外文
WOS：
中科院(CAS)分区：
出版当年[2026]版：
无
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 风湿病学
JCR分区：
出版当年[2025]版：
无
最新[2024]版：
Q1 RHEUMATOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2025版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Minist Sci & Technol, Natl Clin Res Ctr Dermatol & Immunol Dis NCRC DID, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang S.,Xu D.,Wang X.,et al.EFFICACY AND SAFETY OF XELIGEKIMAB IN RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM A PHASE 3 TRIAL[J].ANNALS OF THE RHEUMATIC DISEASES.2025,84:doi:10.1136/annrheumdis-2025-eular.B967.
APA：
Zhang, S.,Xu, D.,Wang, X.,Shujie, L.,Liu, S....&Zeng, X..(2025).EFFICACY AND SAFETY OF XELIGEKIMAB IN RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM A PHASE 3 TRIAL.ANNALS OF THE RHEUMATIC DISEASES,84,
MLA：
Zhang, S.,et al."EFFICACY AND SAFETY OF XELIGEKIMAB IN RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM A PHASE 3 TRIAL".ANNALS OF THE RHEUMATIC DISEASES 84.(2025)

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