Objectives: To analyze global trends in smoking-related disease burden from 1990-2021 and examine associations with health workforce distribution across countries. Methods: We analyzed smoking-related deaths and disability-adjusted life years using Global Burden of Disease 2021 data for 204 countries. Age-standardized rates were calculated for 27 geographic regions. Linear regression assessed temporal trends, while autoregressive integrated moving average models projected future burden to 2050. Correlation analyses examined relationships between 22 health workforce categories and disease burden. Results: Globally, age-standardized death rates from smoking-related diseases increased by 12.3% from 1990-2021, with males showing higher rates than females across all regions. Middle Socio-demographic Index regions exhibited the highest burden. Pharmaceutical technicians demonstrated strong positive correlations with disease burden (r = 0.35-0.37, p < 0.001), while traditional practitioners showed negative correlations (r = -0.24 to -0.28, p < 0.001). Projections indicate continued increases through 2050. Conclusion: Smoking-related disease burden demonstrates significant geographic and temporal variations, with distinct associations between health workforce composition and disease patterns, highlighting the need for targeted prevention strategies.