机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Kunming, Peoples R China外科科室麻醉手术科（医技）昆明医科大学附属第一医院[2]Kunming Med Univ, Yan An Hosp, Dept Pediat, Kunming, Peoples R China[3]Kunming Med Univ, Affiliated Hosp 1, Dept Neurol, Kunming, Peoples R China内科科室神经内科昆明医科大学附属第一医院
Palmitic acid (PA) is a 16-carbon long-chain saturated fatty acid (SFA) in the human body and a major component of dietary SFAs. PA plays a significant regulatory role in the pathogenesis and progression of various diseases, particularly cardiovascular diseases (CVD). The human body acquires PA through endogenous de novo synthesis and exogenous dietary intake, and its concentration in plasma is relatively stable; however, the concentration of PA can increase several-fold in the plasma of patients with CVD. This review focuses on the biosynthetic pathways of PA and its mechanistic involvement in atherosclerosis (AS), ischemic heart disease (IHD), and ischemic stroke (IS). Elucidating the mechanistic contributions of PA to these disease processes may provide critical insights for developing novel targeted therapies.
基金：
National Natural Science Foundation of China [32460138]; Priority Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University [202101AC070461]; Basic Research Program of Yunnan Province Science and Technology Department [202301AT070083]
第一作者机构：[1]Kunming Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Kunming, Peoples R China
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推荐引用方式(GB/T 7714)：
Jiang Huan,Na Chen,Zhu Yangfan,et al.Multiple Roles of Palmitic Acid in Cardiovascular Diseases[J].JOURNAL OF INFLAMMATION RESEARCH.2025,18:14515-14533.doi:10.2147/JIR.S530054.
APA：
Jiang, Huan,Na, Chen,Zhu, Yangfan,Bi, Yibin,Yang, Runxu...&Yang, Juan.(2025).Multiple Roles of Palmitic Acid in Cardiovascular Diseases.JOURNAL OF INFLAMMATION RESEARCH,18,
MLA：
Jiang, Huan,et al."Multiple Roles of Palmitic Acid in Cardiovascular Diseases".JOURNAL OF INFLAMMATION RESEARCH 18.(2025):14515-14533
