Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an unclear etiology and pathophysiology. Previous studies have indicated that the dysregulation of cytokines may be involved in the pathogenesis of ASD and that the levels of cytokines may serve as potential biomarkers of this disorder. Methods The current study employed a family triad-based case-control design to study the levels of plasma cytokines in families with ASD (n = 45 triads) and controls (n = 38 triads) with a Human Cytokine Twenty-Five-Plex Kit. The Social Responsiveness Scale (SRS) was used to measure social impairment of ASD children. Results After controlling for the levels of parental cytokines, we identified that interferon-alpha (IFN-alpha), interleukin-7 (IL-7), IL-8, IFN-gamma-inducible protein-10, and macrophage inflammatory protein-1 beta were associated with ASD, and IL-8 was the only cytokine also associated with the levels of both parental cytokines in the offspring-parents regression analysis and three subdomains of SRS (social awareness, cognition, and motivations) in the children with ASD. The receiver operating characteristic curve showed that the log-transformed IL-8 level discriminated children with autism from controls with an area under the curve of 0.858 (95% confidence interval: 0.777-0.939). Conclusions Our study suggests that IL-8 is a potential biomarker for ASD and may be involved in the pathogenesis of ASD. IMPACT The study suggests that IL-8 is a promising biomarker for ASD and may be involved in the pathogenesis of ASD. Only a very few studies have reported the parental cytokine levels. The significant strength of this article is that we applied the family triad-based approach to explore cytokine levels in families with autism and controls. There are no objective biomarkers, making the accurate diagnosis, prognostic prediction and effective treatment difficult, and our study provides promising results.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81901388, 81974217, 81601197, 81873806]; Major State Basic Research Development Program of China (973 Program)National Basic Research Program of China [2012CB517901]; Humanity and Social Sciences Youth Foundation of Ministry of Education of China [17YJC190022]
第一作者机构:[1]Cent South Univ, China Natl Clin Res Ctr Mental Hlth Disorders, Key Lab Psychiat & Mental Hlth Hunan Prov, Natl Technol Inst Psychiat,Dept Psychiat,Xiangya, Changsha 410011, Hunan, Peoples R China[2]Cent South Univ, China Natl Clin Res Ctr Mental Hlth Disorders, Key Lab Psychiat & Mental Hlth Hunan Prov, Natl Technol Inst Psychiat,Xiangya Hosp 2,Mental, Changsha 410011, Hunan, Peoples R China
通讯作者:
通讯机构:[1]Cent South Univ, China Natl Clin Res Ctr Mental Hlth Disorders, Key Lab Psychiat & Mental Hlth Hunan Prov, Natl Technol Inst Psychiat,Dept Psychiat,Xiangya, Changsha 410011, Hunan, Peoples R China[2]Cent South Univ, China Natl Clin Res Ctr Mental Hlth Disorders, Key Lab Psychiat & Mental Hlth Hunan Prov, Natl Technol Inst Psychiat,Xiangya Hosp 2,Mental, Changsha 410011, Hunan, Peoples R China[6]Cent South Univ, Ctr Med Genet, Changsha 410078, Hunan, Peoples R China[7]Cent South Univ, Sch Life Sci, Changsha 410078, Hunan, Peoples R China[8]Global Clin & Translat Res Inst, Bethesda, MD 20814 USA
推荐引用方式(GB/T 7714):
Shen Yidong,Li Yamin,Shi Lijuan,et al.Autism spectrum disorder and severe social impairment associated with elevated plasma interleukin-8[J].PEDIATRIC RESEARCH.2021,89(3):591-597.doi:10.1038/s41390-020-0910-x.
APA:
Shen, Yidong,Li, Yamin,Shi, Lijuan,Liu, Mengmeng,Wu, Renrong...&Zhao, Jingping.(2021).Autism spectrum disorder and severe social impairment associated with elevated plasma interleukin-8.PEDIATRIC RESEARCH,89,(3)
MLA:
Shen, Yidong,et al."Autism spectrum disorder and severe social impairment associated with elevated plasma interleukin-8".PEDIATRIC RESEARCH 89..3(2021):591-597