Background: On the base of traditional modeling with high-frequency atrial pacing, insertable cardiac monitor is innovatively used to track the incidence of atrial fibrillation (AF), to observe the efficiency and safety of establishment in AF model. Material/Methods: Twelve adult beagle dogs were randomly divided into a blank control group and an AF model group. The thin- nest available bipolar solid electrode lead-3830 was implanted in AF group, connected to AF pacemaker to establish a high-frequency atrial pacing model by AOO pacing mode, and the occurrence of AF was tracked in real time by an insertable cardiac monitor Reveal LINQ. The areas of the left and the right atrium were measured by echocardiography. In addition, the morphology of left atrial tissues was observed using light and electron microscopes. Results: The insertable cardiac monitor Reveal LINQ sensitively, conveniently, accurately, efficiently, and dynamically re- corded the AF load in AF group. After the successfully establishment of the AF mode, the area of the left atrium and right atrium were significantly enlarged compared with that before modeling by echocardiography. Furthermore, the area of the left atrium and right atrium in the AF group were larger than that in the control group. The morphological observation of the left atrium tissues in both groups prompted the reconstruction of the atrial structure in dogs in the AF group. Conclusions: The application of insertable cardiac monitor Reveal LINQ improves the efficiency of monitoring the AF load, with high sensitivity, convenience, and accuracy.
基金:
National Natural Science FoundationNational Natural Science Foundation of China [81560066]; Research Fund for Doctors of the First Affiliated Hospital of Kunming Medical University [2018BS008]; Scientific Research Foundation Project of Yunnan Education Department [2019J1232]; Yunnan Science and Technology DepartmentKunming Medical University Joint Special Fund [2017FE467(-031)]
第一作者机构:[1]Kunming Med Univ, Dept Cardiol, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China
通讯作者:
通讯机构:[1]Kunming Med Univ, Dept Cardiol, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China[3]Yunnan Fuwai Cardiovasc Hosp, Dept Cardiol, Kunming, Yunnan, Peoples R China
推荐引用方式(GB/T 7714):
Zhao Lulu,Hua Baotong,Chen Liling,et al.Application of Insertable Cardiac Monitor in Establishing a Dog Model of Atrial Fibrillation by High-Frequency Right Atrial Pacing[J].MEDICAL SCIENCE MONITOR.2020,26:doi:10.12659/MSM.920071.
APA:
Zhao, Lulu,Hua, Baotong,Chen, Liling,Pu, Lijin,Dai, Rongsu...&Zhao, Ling.(2020).Application of Insertable Cardiac Monitor in Establishing a Dog Model of Atrial Fibrillation by High-Frequency Right Atrial Pacing.MEDICAL SCIENCE MONITOR,26,
MLA:
Zhao, Lulu,et al."Application of Insertable Cardiac Monitor in Establishing a Dog Model of Atrial Fibrillation by High-Frequency Right Atrial Pacing".MEDICAL SCIENCE MONITOR 26.(2020)