BACKGROUND: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. METHODS: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. RESULTS: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -20.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. CONCLUSIONS: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
基金:
Max Planck Society (Germany)Max Planck Society; Japan Society for the Promotion of Science (KAKENHI)Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [18K15523, 16K04344, 16K19778, 18K07608, 26461762]; Carlos III Health InstituteInstituto de Salud Carlos III [PI14/00419]; European Regional Development FundEuropean Union (EU) [FI17/00294, PI16/00950, PI040829]; European Regional Development FundsEuropean Union (EU) [CPII16/00048, PI13/01958, PI16/00889]; Ontario Mental Health Foundation; Alberta Innovates Translational Health Chair in Child and Youth Mental Health; Ontario Brain Institute; National Institute of Mental HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [K23MH104515, K23-MH092397, K23MH082176, R21MH101441, R01MH081864, R01MH085900, R21MH093889]; Fundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/21357-9]; Swiss National Science FoundationSwiss National Science Foundation (SNSF) [320030_130237]; Hartmann Muller Foundation [1460]; David Judah Fund at the Massachusetts General Hospital; EU FP7 Project TACTICSEuropean Union (EU) [278948]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81560233, 81371340]; International OCD Foundation [K23 MH115206]; Wellcome Sir Henry Dale Fellowship [211155/Z/18/Z]; Jacobs Foundation; Brain and Behavior Research Foundation [27023]; Agency for Medical Research and Development [JP18dm0307002]; Michael Smith Foundation for Health ResearchMichael Smith Foundation for Health Research; Federal Ministry of Education and Research of GermanyFederal Ministry of Education & Research (BMBF) [BMBF-01GW0724]; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [KO 3744/7-1]; Helse Vest Health Authority [911754, 911880]; Norwegian Research CouncilResearch Council of Norway [HELSEFORSK 243675]; Marato TV3 Foundation [01/2010, 091710]; Agency for Management of University and Research Grants from the Generalitat de Catalunya [2017 SGR 881, 2017 SGR 1247]; Fundacao para a Ciencia e a TecnologiaPortuguese Foundation for Science and Technology [PDE/BDE/113604/2015, PDE/BDE/113601/2015]; Japanese Ministry of Education, Culture, Sports, Science and TechnologyMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [22591262, 25461732, 16K10253]; Government of India Department of Science and TechnologyDepartment of Science & Technology (India) [IFA12-LSBM26, SR/S0/HS/0016/2011]; Government of India Department of BiotechnologyDepartment of Biotechnology (DBT) India [BT/06/IYBA/2012, BT/PR13334/Med/30/259/2009]; New York State Office of Mental Health; Italian Ministry of HealthMinistry of Health, Italy [RC13-14-15-16A]; National Center for Advancing Translational SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1TR000067/KL2TR00069]; Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR); British Columbia Provincial Health Services Authority; Netherlands Organization for Scientific ResearchNetherlands Organization for Scientific Research (NWO) [NWO/ZonMW Vidi 917.15.318]; Wellcome-DBT India AllianceWellcome Trust DBT India Alliance [500236/Z/11/Z]; Shanghai Key Laboratory of Psychotic Disorders [13dz2260500]; Michael Smith FoundationMichael Smith Foundation for Health Research
Kong Xiang-Zhen,Boedhoe Premika S. W.,Abe Yoshinari,et al.Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium[J].BIOLOGICAL PSYCHIATRY.2020,87(12):1022-1034.doi:10.1016/j.biopsych.2019.04.022.
APA:
Kong, Xiang-Zhen,Boedhoe, Premika S. W.,Abe, Yoshinari,Alonso, Pino,Ameis, Stephanie H....&Francks, Clyde.(2020).Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.BIOLOGICAL PSYCHIATRY,87,(12)
MLA:
Kong, Xiang-Zhen,et al."Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium".BIOLOGICAL PSYCHIATRY 87..12(2020):1022-1034