机构：[1]Department of Dermatology and Venereology, First Afliated Hospital of Kunming Medical University, Kunming 650032, China.内科科室皮肤科昆明医科大学附属第一医院[2]Institute of Infection and Immunity, Henan University & Center for Translational Medicine, Huaihe Clinical College, Huaihe Hospital of Henan University, Kaifeng 475000, China.[3]School of Public Health, Kunming Medical University, Kunming 650500,China.
BackgroundEarly diagnosis of congenital syphilis (CS) is difficult. This study aimed to determine the serological response discipline of syphilis passive antibody (SPA) in infants born to mothers with syphilis and provide the basis for the early diagnosis of CS.MethodsThirty-three infants born to mothers with syphilis and six infants with CS were recruited. The toluidine red unheated serum test (TRUST) and Treponema pallidum particle agglutination (TPPA) titers were followed up after birth.ResultsThe results showed that serological response in the serum of infants with the TPPA titer decreased threefold at 3rd month, or the titer dropped to a minimum of 1:40 at 9th month was SPA. The TPPA titer of 6 CS cases remained positive after 3-year follow-up, and the titer did not decline after treatment and maintained longer. The infants with TRUST titer 1:4 at birth were prone to become syphilis serofast, while TRUST titer <1:4 turned to negative quickly.ConclusionIn infants with SPA, the TRUST converted negative earlier than the TPPA. The lower the TPPA initial titer was, the shorter the seroreversion time required. The TPPA titer can be used to predict CS in infants born to mothers with syphilis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81371812, 81860553]; Project for Innovation Team of Department of Science and Technology of Yunnan Province, China [2018HC005]; Medical Leadership Foundation of Health and Family Planning Commission of Yunnan Province, China [L-201613]; National Science and Technology Major Project of China [2018ZX10301-101]
第一作者机构：[1]Department of Dermatology and Venereology, First Afliated Hospital of Kunming Medical University, Kunming 650032, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Hong-Mei,Li Yu-Ye,He Li-Ping,et al.TPPA titer as a new adaptation for early diagnosis of congenital syphilis: a retrospective analysis of observation over threeyears in Yunnan, China[J].EUROPEAN JOURNAL OF MEDICAL RESEARCH.2019,24:doi:10.1186/s40001-019-0367-8.
APA：
Wang, Hong-Mei,Li, Yu-Ye,He, Li-Ping,Cao, Ying-Kui,Dong, Tian-Xiang&Kuang, Yi-Qun.(2019).TPPA titer as a new adaptation for early diagnosis of congenital syphilis: a retrospective analysis of observation over threeyears in Yunnan, China.EUROPEAN JOURNAL OF MEDICAL RESEARCH,24,
MLA：
Wang, Hong-Mei,et al."TPPA titer as a new adaptation for early diagnosis of congenital syphilis: a retrospective analysis of observation over threeyears in Yunnan, China".EUROPEAN JOURNAL OF MEDICAL RESEARCH 24.(2019)
