机构：[1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China,内科科室神经内科昆明医科大学附属第一医院[2]Department of Neurology, Seventh People’s Hospital of Chengdu, Chengdu, China,[3]Department of Anesthesiology, Chengdu Women and Children’s Central Hospital, Chengdu, China
Objective: The objective of the present study was to meta-analyze relevant literature to gain a comprehensive understanding of the potential relationship between serum uric acid levels and risk of benign paroxysmal positional vertigo (BPPV). Methods: The databases of PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were systematically searched for observational case-control studies of the association between BPPV and serum uric acid levels published up to October 2018. Data fromeligible studies weremeta-analyzed using Stata 12.0. Results: A total of 12 studies were included in the analysis. There was a strong tendency for serum uric acid levels to be associated with risk of BPPV among studies conducted in China (OR 0.69, 95%CI 0.01-1.40, p = 0.053), but not among studies outside China (OR 1.07, 95% CI 1.08-3.22, p = 0.33). Across all studies, serum uric acid level was significantly higher among individuals with BPPV than among controls (OR 0.78, 95%CI 0.15-1.41, p = 0.015), yet it did not independently predict risk of the disorder (OR 1.003, 95%CI 0.995-1.012, p = 0.471). Conclusion: The available evidence suggests that BPPV is associated with elevated levels of serum uric acid, but these levels may not be an independent risk factor of BPPV.
基金：
This research was supported by Yunnan Province MedicalHealth
Research Institute Project (2018NS0102) and The First Affiliated
Hospital of Kunming Medical University Doctoral Research
Fund Project (2017BS005).
第一作者机构：[1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Xinglong Yang,Baiyuan Yang,Mengjun Wu,et al.Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies[J].FRONTIERS IN NEUROLOGY.2019,10:doi:10.3389/fneur.2019.00091.
APA：
Xinglong Yang,Baiyuan Yang,Mengjun Wu,Fang Wang,Xiaodong Huang...&Hui Ren.(2019).Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies.FRONTIERS IN NEUROLOGY,10,
MLA：
Xinglong Yang,et al."Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies".FRONTIERS IN NEUROLOGY 10.(2019)
