机构：[1]Department of Colorectal Cancer Surgery, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University[2]Department of Oncology, the First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology云南省第一人民医院[3]Department of General Surgery, the Second People’s Hospital of Yunnan Province[4]Department of Hepatopancreatobiliary Surgery, the First People’s Hospital of Yunnan Province云南省第一人民医院[5]Department of Radiotherapy, the First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, P. R. China云南省第一人民医院
Colorectal cancer (CRC) is one of the most common cancer diagnoses. Histone deacetylase (HDAC) overactivity in CRC could promote cancer progression. HDAC1, a member of the HDAC family, is found aberrantly expressed in CRC, but it remains unclear whether the expression of HDAC1 can be regulated by microRNA. In the present study, we confirmed the overexpression status of HDAC1 in CRC tissues and cell lines, and its overexpression could promote CRC cell proliferation and invasion in vitro. We saw that HDAC1 was a direct target gene of miR-761 in CRC by bioinformatic and luciferase reporter analyses. HDAC1 expression could be regulated and was negatively correlated with miR-761 in CRC. We also indicated that the expression of miR-761 was abnormally downregulated in CRC. Transfection with a miR-761 mimic impeded the growth and invasion of CRC cells. In addition, we showed that ectopic expression of miR-761 mitigated HDAC1 stimulation of CRC cell proliferation and invasion. Our results demonstrate that miR-761 represents a potential strategy against CRC.
基金：
This work was supported by Yunnan Medical Leaders Foundation (No. L-2017016)
and Yunnan Applied Basic Research Foundation (No. 2017FE468(-245)).
第一作者机构：[1]Department of Colorectal Cancer Surgery, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University
通讯作者：
通讯机构：[*1]Department of Hepatopancreatobiliary Surgery, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming 650032, P. R. China[*2]Department of Radiotherapy, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Wuhua District, Kunming 650032, P. R. China
推荐引用方式(GB/T 7714)：
WEI XIONG,SHU YANG,WANFU ZHANG,et al.MiR-761 inhibits colorectal cancer cell proliferation and invasion through targeting HDAC1[J].PHARMAZIE.2019,74(2):111-114.doi:10.1691/ph.2019.8756.
APA：
WEI XIONG,SHU YANG,WANFU ZHANG,YESHENG CHEN&FENG WANG.(2019).MiR-761 inhibits colorectal cancer cell proliferation and invasion through targeting HDAC1.PHARMAZIE,74,(2)
MLA：
WEI XIONG,et al."MiR-761 inhibits colorectal cancer cell proliferation and invasion through targeting HDAC1".PHARMAZIE 74..2(2019):111-114
