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Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: A multicenter study(Open Access)

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收录情况： ◇ SCIE

作者：
Xian-Rui Wu[1,2] ; Xiao-Bin Zheng[1,2] ; Yan Huang[2,3] ; Qian Cao[4] ; Hong-Jie Zhang[5] ; Ying-Lei Miao[6] ; Kai-Fang Zou[7] ; Min Chen[8] ; Fa-Ming Zhang[9] ; Qiao Mei[10] ; David Gonzalo[11] ; Daniela Allende[12] ; Pin-Jin Hu[2,13] ; Bo Shen[14] ; Xiu-Li Liu[11] ; Ping Lan[1,2,*1] ;
机构： [1]Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China, [2]Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, [3]Department of Pathology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China, [4]Department of Gastroenterology, Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, China, [5]Department of Gastroenterology, Jiangsu Province Hospital, Nanjing, China, [6]Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China, [7]Department of Gastroenterology, Wuhan Union Hospital, Wuhan, China, [8]Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China, [9]Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China, [10]Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, China, [11]Department of Pathology and Laboratory Medicine, University of Florida, Gainesville, FL, USA, [12]Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, OH, USA, [13]Department of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China [14]Department of Gastroenterology/Hepatology, The Cleveland Clinic Foundation, Cleveland, OH, USA
出处：
DOI： 10.1093/gastro/goy039
ISSN：

关键词： Colorectal neoplasia Inflammatory bowel disease Risk factor

摘要：
Background: This study sought to evaluate the risk factors for the development of colitis-associated neoplasia (CAN) in Chinese patients with inflammatory bowel disease (IBD). Methods: IBD patients who developed CAN between 1999 and 2016 were identified from eight medical centers. In addition to initial pathology evaluation, a CAN diagnosis was confirmed by two expert pathologists. Patients with CAN (n ¼ 29) were compared with non-CAN controls (n ¼ 87). Matching was performed for gender and IBD type with a ratio of three controls to one subject. Results: Of the 29 patients with CAN, 8 (27.6%) had colorectal cancer (CRC), 20 (69.0%) had a final diagnosis of low-grade dysplasia and 1 (3.4%) had high-grade dysplasia. Multivariate analysis revealed that an older age at the time of IBD diagnosis and a longer IBD duration were independent risk factors for the development of CAN, with odds ratios of 1.09 [95% confidence interval (CI): 1.04-1.14, P < 0.001] and 1.14 (95% CI: 1.03-1.27, P ¼ 0.013), respectively. Comparison between IBD patients with CRC and those with dysplasia indicated that the former were older at the time of IBD diagnosis (P ¼ 0.012) and had longer IBD durations (P ¼ 0.019). Conclusions: Older age at the time of IBD diagnosis and longer IBD duration were found to be associated with the development of CAN in IBD patients. © The Author(s) 2018. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-Sen University

基金：
This work was supported by National Key Clinical Discipline, National Natural Science Foundation of China (No. 81870383), Guangdong Natural Science Foundation (No. 2017A030313785), Science and Technology Planning Project of Guangzhou City (No. 201804010014), and Science and Technology Planning Project of Guangdong Province (No. 2015B020229001).
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外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 4 区 胃肠肝病学
最新[2023]版：
大类 | 3 区 医学
小类 | 4 区 胃肠肝病学
JCR分区：
出版当年[2019]版：
Q3 GASTROENTEROLOGY & HEPATOLOGY
最新[2023]版：
Q2 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China, [2]Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China,
共同第一作者：
通讯作者：
通讯机构： [1]Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China, [2]Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, [*1]Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong 510655, China
推荐引用方式(GB/T 7714)：
Xian-Rui Wu,Xiao-Bin Zheng,Yan Huang,et al.Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: A multicenter study(Open Access)[J].GASTROENTEROLOGY REPORT.2019,7(1):67-73.doi:10.1093/gastro/goy039.
APA：
Xian-Rui Wu,Xiao-Bin Zheng,Yan Huang,Qian Cao,Hong-Jie Zhang...&Ping Lan.(2019).Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: A multicenter study(Open Access).GASTROENTEROLOGY REPORT,7,(1)
MLA：
Xian-Rui Wu,et al."Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease: A multicenter study(Open Access)".GASTROENTEROLOGY REPORT 7..1(2019):67-73

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