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Inhibition of SOX15 Sensitizes Esophageal Squamous Carcinoma Cells to Paclitaxel

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收录情况： ◇ SCIE

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机构： [1]Hangzhou Canc Hosp, Dept ICU, Hangzhou 320001, Zhejiang, Peoples R China; [2]Kunming Med Univ, Affiliated Hosp 1, Minist Hlth, Key Lab Drug Addict Med, Kunming 650032, Yunnan, Peoples R China; [3]Kunming Med Univ, Affiliated Hosp 1, Yunnan Inst Digest Dis, Kunming 650032, Yunnan, Peoples R China; [4]Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol Crit Care & Pain Med, Wenzhou 325027, Zhejiang, Peoples R China; [5]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China

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关键词： SOX15 ESCC Paclitaxel RNAi WNT NOTCH

摘要：

Background: SOX15 is a crucial transcription factor involved in the regulation of embryonic development and in the cell fate determination. It is also an important mediator of tumorigenesis in cancer. Methods: Here, we sought to explore the expression patterns and biological functions of SOX15 in esophageal squamous cell carcinomas (ESCC). SOX15 was found aberrantly overexpressed in ESCC tumors. Results: Experimentally, inhibition of SOX15 through RNAi suppressed cell proliferation in ESCC cells and sensitized cancer cells to paclitaxel, but not to Cisplatin. Moreover, inhibition of SOX15 significantly repressed the expression of genes associated with WNT and NOTCH signaling pathways, which may contribute to the increased sensitivity to paclitaxel. Conclusion: In conclusion, the current study revealed that inhibition of SOX15 in ESCC cells sensitizes the ESCC cells to paclitaxel, suggesting that the SOX15 expression level may predict the therapeutic outcomes for paclitaxel treatment for ESCC.

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

JCR分区：

出版当年[2019]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.2 最新[2023版] 2.1 最新五年平均 1.6 出版当年[2019版] 2.388 出版当年五年平均 2.196 出版前一年[2018版] 2.222 出版后一年[2020版]

第一作者：

第一作者机构： [1]Hangzhou Canc Hosp, Dept ICU, Hangzhou 320001, Zhejiang, Peoples R China;

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通讯机构： [2]Kunming Med Univ, Affiliated Hosp 1, Minist Hlth, Key Lab Drug Addict Med, Kunming 650032, Yunnan, Peoples R China;

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