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Autophagy in pulmonary hypertension: Emerging roles and therapeutic implications

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People’s Hospital of Yunnan, Kunming, Yunnan, China [2]Department of Pharmacy, Yan’An Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China [3]First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

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关键词： autophagy pulmonary artery endothelial cells pulmonary artery smooth muscle cells pulmonary hypertension

摘要：

Autophagy is an important mechanism for cellular self-digestion and basal homeostasis. This gene- and modulator-regulated pathway is conserved in cells. Recently, several studies have shown that autophagic dysfunction is associated with pulmonary hypertension (PH). However, the relationship between autophagy and PH remains controversial. In this review, we mainly introduce the effects of autophagy-related genes and some regulatory molecules on PH and the relationship between autophagy and PH under the conditions of hypoxia, monocrotaline injection, thromboembolic stress, oxidative stress, and other drugs and toxins. The effects of other autophagy-related drugs, such as chloroquine, 3-methyladenine, rapamycin, and other potential therapeutic drugs and targets, in PH are also described.

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出版当年[2020]版：

大类 | 2 区生物

小类 | 2 区生理学 3 区细胞生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 2 区生理学 3 区细胞生物学

JCR分区：

出版当年[2019]版：

Q1 PHYSIOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q1 PHYSIOLOGY Q2 CELL BIOLOGY

影响因子： 4.5 最新[2023版] 5.3 最新五年平均 5.546 出版当年[2019版] 4.834 出版当年五年平均 4.522 出版前一年[2018版] 6.384 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People’s Hospital of Yunnan, Kunming, Yunnan, China

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通讯作者：

通讯机构： [*1]Department of Respiratory Medicine, The Fourth Affiliated Hospital of Kunming Medical University, The Second People’s Hospital of Yunnan Province, No. 176, Qingnian Road, Kunming, 650021 Yunnan, China. [*2]First Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, 650032 Yunnan, China.

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