机构：[1]Department of Geriatrics, Yan’an Affiliated Hospital of Kunming Medical University, Kunming, China[2]Key Laboratory of Cardiovascular Disease of Yunnan Province, Kunming, China[3]Department of Cardiology, 1st Affiliated Hospital of Kunming Medical University, Kunming, China内科科室心脏内科昆明医科大学附属第一医院[4]Department of Ultrasound, 2nd Affiliated Hospital of Kunming Medical University, Kunming, China.
Cardiac Shock Wave Therapy (CSWT) improves myocardial perfusion and ameliorates cardiac remodeling after acute myocardial infarction (AMI), but the precise mechanisms remain obscure. Herein, we have applied CSWT to a rat model of AMI to demonstrate the arteriogenesis of coronary micrangium and protein expression changes in ischemic myocardium after CSWT. Four weeks after CSWT, the fraction shortening of rats was improved greatly and the cardiomyocyte apoptosis index was significantly lower than the AMI group (P < 0.05). Besides, the fibrotic area was markedly decreased in the CSWT group. In the infarction border zone, the thickness of smooth muscle layer was expanded apparently after CSWT. Label-free quantitative proteomic analysis and bioinformatics analysis revealed that the differentially expressed proteins were largely enriched in the focal adhesion signaling pathway. And integrin linked kinase (ILK) may be a key factor contributed to arteriogenesis of coronary micrangium during CSWT. In conclusion, non-invasive cardiac shock wave could promote arteriogenesis of coronary micrangium and alleviate myocardial apoptosis and fibrosis after AMI. Furthermore, focal adhesion signaling pathway may have a central role in the related signal network and ILK was closely related to the arteriogenesis of coronary micrangium during CSWT.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81260027]; Technology Department Program of Yunnan Province [2014FZ051]
第一作者机构：[1]Department of Geriatrics, Yan’an Affiliated Hospital of Kunming Medical University, Kunming, China[2]Key Laboratory of Cardiovascular Disease of Yunnan Province, Kunming, China
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Wenhui,He Yan,Gan Lulu,et al.Cardiac shock wave therapy promotes arteriogenesis of coronary micrangium, and ILK is involved in the biomechanical effects by proteomic analysis[J].SCIENTIFIC REPORTS.2018,8:doi:10.1038/s41598-018-19393-z.
APA：
Yang, Wenhui,He, Yan,Gan, Lulu,Zhang, Fan,Hua, Baotong...&Guo, Tao.(2018).Cardiac shock wave therapy promotes arteriogenesis of coronary micrangium, and ILK is involved in the biomechanical effects by proteomic analysis.SCIENTIFIC REPORTS,8,
MLA：
Yang, Wenhui,et al."Cardiac shock wave therapy promotes arteriogenesis of coronary micrangium, and ILK is involved in the biomechanical effects by proteomic analysis".SCIENTIFIC REPORTS 8.(2018)
