机构：[1]State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin, 300020, China[2]Department of Hematology, The First Affiliated Hospital of Kunming Medical University, Hematology Research Center of Yunnan Province, Kunming, 650032, China内科科室血液内科昆明医科大学附属第一医院[3]Central Laboratory, The Union Hospital of Fujian Medical University, Fuzhou, 350001, China
Alveolar macrophages (AMs) are pivotal for maintaining the lung homeostasis, but how the development and function of AMs regulated remains largely unknown. In the present study, we demonstrated that the number of AMs was controlled by the Tsc1 protein. Cd11c-specific deletion of Tsc1 caused inefficient transition from pre-AMs to AMs in lung, which led to a great reduction of AM population. Ablation of Tsc1 downregulated the expression of surface marker CD64 and SiglecF on AMs. We further showed that conditional knockout of Tsc1 led to enhanced proliferation and increased reactive oxygen species (ROS) production and phagocytosis in AMs. These results indicated that Tsc1 was a critical regulator of development, proliferation and function in AMs. (C) 2018 Elsevier Inc. All rights reserved.
基金：
National Basic Research Program of ChinaNational Basic Research Program of China [2015CB964402, 2013CB966904]; CAMS Initiative for Innovative Medicine [2016-I2M-1-003, 2017-I2M-1-015]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81421002, 81670107, 81760035]; Tianjin Outstanding Youth Funds [17JCJQJC45800]
第一作者机构：[1]State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin, 300020, China
通讯作者：
通讯机构：[*1]State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Disease, Peking Union Medical College, Chinese Academy of Medical Sciences, 288 Nanjing Road, Tianjin, 300020, China
推荐引用方式(GB/T 7714)：
Chen Song,Yang Qiongmei,Liu Jingru,et al.Tsc1 controls the development and function of alveolar macrophages[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2018,498(3):592-596.doi:10.1016/j.bbrc.2018.03.027.
APA：
Chen, Song,Yang, Qiongmei,Liu, Jingru,Huang, Huifang,Shi, Mingxia&Feng, Xiaoming.(2018).Tsc1 controls the development and function of alveolar macrophages.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,498,(3)
MLA：
Chen, Song,et al."Tsc1 controls the development and function of alveolar macrophages".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 498..3(2018):592-596
