机构：[1]Peking University People’s Hospital, Peking University Hepatology Institute,Beijing Key Laboratory for Hepatitis C and Immunotherapy for Liver Disease,Beijing, China[2]Henan Provincial People’s Hospital, Zhengzhou, China[3]FirstHospital of Lanzhou University, Lanzhou, China[4]First Affiliated Hospital withNanjing Medical University, Nanjing, China江苏省人民医院[5]Shanghai Ruijin Hospital,Shanghai, China[6]Third Affiliated Hospital of Sun Yat-sen University,Guangzhou, China中山大学附属第三医院[7]Second Hospital of Shandong University, Jinan, China[8]First Affiliated Hospital of Kunming Medical College, Kunming, China昆明医科大学附属第一医院云南省第一人民医院[9]FirstAffiliated Hospital of Guangxi Medical University, Nanning, China[10]NanfangHospital, Southern Medical University, Guangzhou, China[11]First AffiliatedHospital of Fujian Medical University, Fuzhou, China
Background: Hepatitis C virus (HCV) infection is one of the most common liver infections, with a decrement in HRQoL of HCV patients. This study aims to assess Health-related quality of life (HRQoL) in Chinese patients with chronic HCV infection, and to identify significant predictors of the HRQoL in these patients of China. Methods: In this cross-sectional observational study, treatment-naive Han ethnic adults with chronic HCV infection were enrolled. Adopting European Quality of Life scale (EQ-5D) and EuroQOL visual analogue scale (EQ-VAS) were used to qualify HRQoL. Results were reported in descriptive analyses to describe sociodemographic and clinical characteristics. Multiple linear regression analysis was applied to investigate the associations of these variables with HRQoL. Binary logistic regression analysis was performed to identify associations of these variables with HRQoL by dimensions of EQ-5D. Results: Nine hundred ninety-seven patients were enrolled in the study [ median age 46.0 (37.0, 56.0) years; male 54.8%]. Mean EQ-5D index and EQ-VAS score were 0.780 +/- 0.083 and 77.2 +/- 14.8. Multiple Linear regression analysis showed that income (< 2000 RMB, beta = -0.134; 2000-4999 RMB, beta = -0.085), moderate or severe symptoms of discomfort (more than one symptoms, beta = -0.090), disease profile (cirrhosis, beta = -0.114), hyperlipidemia (beta =-0.065) and depression (beta = -0.065) were independently associated with EQ-5D index. Residence (the west, beta = 0.087), income (< 2000 RMB, beta = -0.129; 2000-4999 RMB, beta = -0.052), moderate or severe symptoms of discomfort (more than one symptoms, beta = -0.091), disease profile and depression (beta = -0.316) were the influencing factors on EQ-VAS. Binary logistic regression indicated that disease profile and clinical depression were the major influencing factors on all five dimensions of EQ-5D. Conclusions: In this cross-sectional assessment of HCV patients in China, we indicated HRQoL of Chinese HCV patients. Significant negative associations between HRQoL and sociodemographic and clinical factors such as moderate or severe symptoms of discomfort, disease profile and depression emerged. We have to focus on optimally managing care of HCV patients and improving their HRQoL.
基金：
China National Science and Technology Major Project for Infectious Diseases Control [2008ZX10002-013, 2008ZX10002-012, 2012ZX10002003]; Bristol-Myers SquibbBristol-Myers Squibb
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|3 区卫生保健与服务
最新[2023]版：
大类|2 区医学
小类|2 区卫生保健与服务2 区卫生政策与服务
JCR分区：
出版当年[2018]版：
Q2HEALTH POLICY & SERVICESQ2HEALTH CARE SCIENCES & SERVICES
最新[2023]版：
Q1HEALTH CARE SCIENCES & SERVICESQ1HEALTH POLICY & SERVICES
第一作者机构：[1]Peking University People’s Hospital, Peking University Hepatology Institute,Beijing Key Laboratory for Hepatitis C and Immunotherapy for Liver Disease,Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Huang Rui,Rao Huiying,Shang Jia,et al.A cross-sectional assessment of health-related quality of life in Chinese patients with chronic hepatitis c virus infection with EQ-5D[J].HEALTH AND QUALITY OF LIFE OUTCOMES.2018,16:doi:10.1186/s12955-018-0941-8.
APA：
Huang, Rui,Rao, Huiying,Shang, Jia,Chen, Hong,Li, Jun...&Wei, Lai.(2018).A cross-sectional assessment of health-related quality of life in Chinese patients with chronic hepatitis c virus infection with EQ-5D.HEALTH AND QUALITY OF LIFE OUTCOMES,16,
MLA：
Huang, Rui,et al."A cross-sectional assessment of health-related quality of life in Chinese patients with chronic hepatitis c virus infection with EQ-5D".HEALTH AND QUALITY OF LIFE OUTCOMES 16.(2018)
