机构：[1]Department of Orthopaedics, Bone and Soft Tissue Tumors Research Center of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China[2]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China[3]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China外科科室骨科昆明医科大学附属第一医院
The Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a subtype of bone cancer, is commonly seen in children and adolescents. Typically, pulmonary osteosarcoma metastases are especially difficult to control. In the present paper, we summarise recent studies on the regulation of osteosarcoma progression and metastasis by downregulating Hh signalling. We also summarise the crosstalk between the Hh pathway and other cancer-related pathways in the tumourigenesis of various cancers. We further summarise and highlight the therapeutic value of potential inhibitors of Hh signalling in the clinical therapy of human cancers.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [U1702283, 81760520, 81560471, 31300624, 81460440]; Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University [2017FE467(-073)]; Scientific Research Projects from Internal Research Institutions of Medical and Health Units in Yunnan PFoundation of the Yunnan Provincial Innovative Team of Bone and Soft Tissue Tumor [2015HC026]; Foundation of the Young and Middle-aged Academic and Technical Leaders of Yunnan Province [2014HB034]
第一作者机构：[1]Department of Orthopaedics, Bone and Soft Tissue Tumors Research Center of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yao Zhihong,Han Lei,Chen Yongbin,et al.Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma[J].CELL DEATH & DISEASE.2018,9:doi:10.1038/s41419-018-0647-1.
APA：
Yao, Zhihong,Han, Lei,Chen, Yongbin,He, Fei,Sun, Bin...&Yang, Zuozhang.(2018).Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma.CELL DEATH & DISEASE,9,
MLA：
Yao, Zhihong,et al."Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma".CELL DEATH & DISEASE 9.(2018)
生物学