An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women
机构：[1]Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, PR China内科科室内分泌科昆明医科大学附属第一医院[2]Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Womens University, Japan[3]Computer Science Department, School of Computing, University of South Alabama, USA[4]College of Math and Computer Science, Fuzhou University, PR China[5]School of Information, Qilu University of Technology (Shandong Academy of Sciences), PR China[6]Department of Geriatric Endocrinology, First Affiliated Hospital of Kunming Medical University, PR China内科科室干疗科内分泌科老年内分泌科昆明医科大学附属第一医院[7]Department of Health Outcomes and Policy, University of Florida, USA[8]Department of Food Sciences and Nutrition, School of Human Environmental Science, Mukogawa Womens University, Japan[9]Research Institute for Nutrition Sciences, Mukogawa Womens University, Japan
Prior research has indicated that as an important biomarker of chronic low-grade inflammation, high-sensitivity C-reactive protein (hs-CRP) can play important roles on the onset of metabolic syndrome and cardiovascular diseases (CVD). We conducted an integrative approach, which combines biological wet-lab experiments, statistical analysis, and semantics-oriented bioinformatics & computational analysis, to investigate the association among hs-CRP, body fat mass (FM) distribution, and other cardiometabolic risk factors in young healthy women. Research outcomes in this study resulted in two novel discoveries. Discovery 1: There are four primary determinants for hs CRP, i.e., central/abdominal FM (a.k.a. trunk FM) accumulation, leptin, high density lipoprotein cholesterol (HDL-C), and plasminogen activator inhibitior-1 (PAI-1). Discovery 2: Chronic inflammation may involve in adipocyte-cytokine interaction underlying the metabolic derangement in healthy young women.
基金：
Open Research Center Project for Private University: Matching Fund Subsidy for Private Universities, The Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; National Natural Science Fund of China (NSFC)National Natural Science Foundation of China [81660141]; Applied Basic Research of Yunnan Provincial Science and Technology Department [2015FB023]; National Cancer Institute (NCI) of the National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [U01CA180982]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|2 区生物
小类|2 区生化研究方法3 区生化与分子生物学
最新[2023]版：
大类|3 区生物学
小类|3 区生化研究方法3 区生化与分子生物学
JCR分区：
出版当年[2018]版：
Q1BIOCHEMICAL RESEARCH METHODSQ2BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q1BIOCHEMICAL RESEARCH METHODSQ2BIOCHEMISTRY & MOLECULAR BIOLOGY
第一作者机构：[1]Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, PR China[2]Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Womens University, Japan[*1]Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, PR China
通讯作者：
通讯机构：[*1]Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, PR China
推荐引用方式(GB/T 7714)：
Wu Bin,Huang Jingshan,Zhang Lihua,et al.An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women[J].METHODS.2018,145:60-66.doi:10.1016/j.ymeth.2018.04.016.
APA：
Wu, Bin,Huang, Jingshan,Zhang, Lihua,Kasukurthi, Mohan Vamsi,Huang, Fangwan...&Kazumi, Tsutomu.(2018).An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women.METHODS,145,
MLA：
Wu, Bin,et al."An integrative approach to investigate the association among high-sensitive C-reactive protein, body fat mass distribution, and other cardiometabolic risk factors in young healthy women".METHODS 145.(2018):60-66
