机构：[1]Division of Microbiology, Peking Union Medical College Hospital, PekingUnion Medical College, Chinese Academy of Medical Sciences, No.1Shuaifuyuan, Wangfujing Street, Beijing 100730, China[2]Department ofMicrobiology, The First Affiliated Hospital of Zhejiang University, Hangzhou310003, China浙江大学医学院附属第一医院[3]Department of Infectious Diseases, SirRunRun Shaw Hospital,School of Medicine, Zhejiang University, Hangzhou 310016, China[4]InfectionControl Center, Xiangya Hospital, Central South University, Changsha 410008,China[5]Microbiology Laboratory, Jilin Province People’s Hospital, Changchun130021, China[6]The Fourth Hospital of Harbin Medical University, No.37Yiyuan Road, Nangang District, Harbin, China[7]Division of Microbiology,Haikou People’s Hospital, Haikou 570208, China[8]Department of LaboratoryMedicine, Tongji Hospital, Tongji Medical College, Huazhong University ofScience and Technology, Wuhan 430030, China华中科技大学同济医学院附属同济医院[9]Division of Microbiology,Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai200025, China[10]Nanjing General Hospital, No.305Zhongshan Dong Road,Nanjing, China[11]Department of Laboratory Medicine, Shandong ProvincialHospital Affiliated to Shandong University, Jinan 250021, China[12]Division ofMicrobiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou510080, China中山大学附属第一医院[13]Zhongshan Hospital Affiliated to Fudan University, No .180Fenglin Road, Shanghai 200032, China[14]Beijing Chao-yang Hospital, 8Gongren Tiyuchang Nanlu, Chaoyang District, Beijing 100020, China北京朝阳医院[15]Division of Microbiology, The First Affiliated Hospital of Chongqing MedicalUniversity, Chongqing 400016, China重庆医科大学附属第一医院[16]Clinical laboratory, The SecondAffiliated Hospital of Nanchang University, Nanchang 330006, China[17]FirstAffiliated Hospital of Kunming Medical University, No .295 Xichang Road,Kunming 650032, China昆明医科大学附属第一医院[18]Division of Microbiology, International HealthManagement Associates, Schaumburg, IL 60173-3817, USA
Background: To evaluate the susceptibility rates of aerobic and facultative Gram-negative bacterial isolates from Chinese intra-abdominal infections (IAI) and urinary tract infections (UTI) focusing on carbapenems and comparing their effectiveness between 2014 and 2015. Methods: A total of 2318 strains in 2015 (1483 from IAI and 835 from UTI) and 2374 strains in 2014 (1438 from IAI and 936 from UTI) were included in the analysis. Antimicrobial susceptibilities were determined at a central laboratory using CLSI broth microdilution and interpretive standards. Hospital acquired (HA) IAI and UTI were defined as isolates sampled > 48 h and community acquired (CA) as isolates sampled < 48 h after admission. Results: The main species derived from IAI and UTI in 2015 were Escherichia coli (50.86%) and Klebsiella pneumoniae (19.20%). Susceptibilities of Escherichia coli IAI and UTI strains to imipenem (IPM) and ertapenem (ETP) were > 90% in 2014 and 2015, while the susceptibilities to IPM and ETP of Klebsiella pneumoniae IAI strains were > 80% in 2014 but dropped to <= 80% in 2015 for UTI strains. Susceptibilities of IAI Enterobacteriaceae strains to IPM and ETP in 2015 were lowest in the colon and abscesses, and Enterobacteriaceae susceptibilities of UTI and IAI isolates to IPM and ETP were lowest in medical, pediatric and surgery intensive care units (ICUs) in 2015. Conclusions: IPM and ETP were effective in vitro against Enterobacteriaceae isolated from IAIs and UTIs in 2014 and 2015, but susceptibility to carbapenems in UTIs markedly decreased in 2015.
基金：
Outstanding Talents Training Funding Project of Dongcheng District, Beijing; National Key Research and Development Program of China [SQ2018YFC120102]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-014]; CAMS Initiative for Innovative Medicine [2016-I2M-3-014]; Merck Sharp Dohme (MSD; Whitehouse Station, NJ, USA)
第一作者机构：[1]Division of Microbiology, Peking Union Medical College Hospital, PekingUnion Medical College, Chinese Academy of Medical Sciences, No.1Shuaifuyuan, Wangfujing Street, Beijing 100730, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hui Zhang,Haishen Kong,Yunsong Yu,et al.Carbapenem susceptibilities of Gram-negative pathogens in intra-abdominal and urinary tract infections: updated report of SMART 2015 in China[J].BMC INFECTIOUS DISEASES.2018,18:doi:10.1186/s12879-018-3405-1.
APA：
Hui Zhang,Haishen Kong,Yunsong Yu,Anhua Wu,Qiong Duan...&Yingchun Xu.(2018).Carbapenem susceptibilities of Gram-negative pathogens in intra-abdominal and urinary tract infections: updated report of SMART 2015 in China.BMC INFECTIOUS DISEASES,18,
MLA：
Hui Zhang,et al."Carbapenem susceptibilities of Gram-negative pathogens in intra-abdominal and urinary tract infections: updated report of SMART 2015 in China".BMC INFECTIOUS DISEASES 18.(2018)
