机构：[1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, People’s Republic of China内科科室外科科室神经内科泌尿外科昆明医科大学附属第一医院[2]Department of Neurology, The Seventh People’s Hospital of Chengdu, Chengdu 650041, Sichuan, People’s Republic of China[3]Department of Anesthesia, Kunming Xishan District People’s Hospital, Kunming 650100, Yunnan, People’s Republic of China[4]Department of Neurology, West China Hospital, SCU, Chengdu 650041, Sichuan, People’s Republic of China四川大学华西医院
ObjectiveRecent studies have shown an association between migraine and restless legs syndrome (RLS), but RLS prevalence among individuals with migraine differs substantially across studies. The present work aimed to comprehensively assess available evidence to estimate RLS prevalence among individuals with migraine and non-migraine controls.MethodWeb of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed databases were searched for observational and case-control studies of RLS prevalence among individuals with migraine. Eligible studies were meta-analyzed using Stata 12.0 software.ResultsPooled RLS prevalence in migraine was 19%, and the prevalence was lower in Asia (16%) than outside Asia (21%). Pooled RLS prevalence was 18.8% among individuals with migraine with aura, and 18.5% among individuals with migraine without aura; the RLS prevalence in migraine with aura (MA) was higher than that of migraine without aura (MO) (OR 1.17, 95%CI 1.01-1.34; p=0.037). Pooled RLS prevalence in a case-control study was significantly higher among individuals with migraine (17.9%) than among non-migraine controls (7.1%) (OR 2.65, 95%CI 2.26-3.10; p<0.001).ConclusionOur meta-analysis provides the first reliable pooled estimate of RLS prevalence among individuals with migraine, and it provides strong evidence that RLS risk is higher among individuals with migraine than among controls.
基金：
Yunnan Province Medical Health Research Institute Project [2018NS0102]; First Affiliated Hospital of Kunming Medical University Doctoral Research Fund Project [2017BS005]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81371281]
第一作者机构：[1]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, People’s Republic of China
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推荐引用方式(GB/T 7714)：
Yang Xinglong,Liu Bin,Yang Baiyuan,et al.Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies[J].NEUROLOGICAL SCIENCES.2018,39(11):1927-1934.doi:10.1007/s10072-018-3527-7.
APA：
Yang, Xinglong,Liu, Bin,Yang, Baiyuan,Li, Shimei,Wang, Fang...&Xu, Zhong.(2018).Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies.NEUROLOGICAL SCIENCES,39,(11)
MLA：
Yang, Xinglong,et al."Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies".NEUROLOGICAL SCIENCES 39..11(2018):1927-1934
