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Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis

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机构： [1]Department of Psychiatry and the Department of Anatomy and Neurosciences, VUUniversity MedicalCenter, Amsterdam [2]Neuroscience Campus Amsterdam, Free University/VU University Medical Center, Amsterdam [3]the Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan [4]the Centre for Addiction and Mental Health and Hospital for Sick Children, Toronto [5]theMathison Centre for Mental Health Research and Education, Cumming School of Medicine, University of Calgary, Calgary, Canada [6]the Department of Psychiatry, Institute of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil [7]Clinical Research Group Psychiatry and Clinical Psychobiology, Division of Neuroscience, Scientific Institute Ospedale San Raffaele,Milan [8]the Department of Psychology, Humboldt- Universität zu Berlin, Berlin [9]the Obsessive-Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India [10]the Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich [11]Magnetic Resonance Image Core Facility, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain [12]the Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China [13]the Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Korea [14]the Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam [15]the Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam [16]the DepartmentofPsychiatry, University of Michigan, AnnArbor [17]the Department of Psychiatry, University of Cape Town, Cape Town, South Africa [18]the Department of Psychiatry, University of Stellenbosch, Cape Town [19]the Department of Psychiatry, Bellvitge University Hospital, Bellvitge BiomedicalResearch Institute–IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain [20]Centro de Investigación Biomèdica en Red de Salud Mental (CIBERSAM), Barcelona [21]the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. [22]the Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey [23]De Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam [24]the Department of Child and Adolescent Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam [25]the Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan [26]the Department of Neuroradiology, Klinikumrechts der Isar, Technische Universität München, Munich [27]TUMNeuroimaging Center (TUM-NIC) of Klinikum rechts der Isar, Technische Universität München, Munich [28]the Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea [29]the Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain [30]Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona [31]the Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain [32]SU/UCT MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa [33]Columbia University Medical Center, New York [34]the Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute and Columbia University, New York [35]the Department of Clinical Neuroscience, Center for Psychiatric Research and Education, Karolinska Institutet, Stockholm [36]the Department of Clinical Sciences, University of Barcelona, Barcelona, Spain [37]the Mood Disorders Clinic and the Anxiety Treatment and Research Center, St. Joseph’s HealthCare, Hamilton, Canada [38]the Departmentof NeuralComputation for DecisionMaking,ATR Brain Information Communiciation Research Laboratory Group, Kyoto, Japan [39]the Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome [40]the Center of Mathematics, Computation, and Cognition, Universidade Federal Do ABC, Santo Andre, Brazil [41]the Center for OCD and Related Disorders,New York State Psychiatric Institute, New York [42]the Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain [43]the Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston [44]the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. [45]the Clinical Neuroscience and Development Laboratory, Olin Neuropsychiatry Research Center, Hartford, Conn. [46]the Department of Psychiatry, Icahn School of Medicine atMountSinai,NewYork [47]theJamesJ. PetersVAMedicalCenter,Bronx, New York [48]the Institute of Living/Hartford Hospital, Hartford, Conn. [49]the Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China [50]the Shanghai Key Laboratory of Psychotic Disorders, Shanghai [51]the Department of Internal Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China

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Objective: Structural brain imaging studies in obsessive compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta and mega-analyses of data from OCD sites worldwide. Method: T-1 images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. Results: The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. Conclusions: The results indicate different patterns of sub cortical abnormalities in pediatric and adult OCD patients. The patlidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful.

基金：

基金编号： KO 3744/2-1 RC10-11-12-13-14-15A 500236/Z/11/Z 320030_130237 091710 064846 NWO VIDI 917-15-318 PI13/00918 1460 BT/PR13334/Med/30/259/2009 2014 SGR 489 2014 SGR 1672 U54 EB020403-02 CP10/00604 CP10/00604 26461753 BT/06/IYBA/2012 IFA12-LSBM-26 PI14/00413/PI040829 01/2010 PI13/01958 SR/S0/HS/0016/2011

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大类 | 1 区

医学

小类 | 1 区精神病学

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大类 | 1 区

医学

小类 | 1 区精神病学

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Q1 PSYCHIATRY

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Q1 PSYCHIATRY

影响因子： 15.1 最新[2023版] 17.7 最新五年平均 13.396 出版当年[2017版] 13.92 出版当年五年平均 14.176 出版前一年[2016版] 13.655 出版后一年[2018版]

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第一作者机构： [1]Department of Psychiatry and the Department of Anatomy and Neurosciences, VUUniversity MedicalCenter, Amsterdam

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Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis